Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type-1 Ion Channel

Nagy, I.; Friston, Dominic; Valente, João de Sousa; Torres-Pérez, Jose Vicente; Andreou, Anna P.

doi:10.1007/978-3-0348-0828-6_2

Cited by 44 publications

(49 citation statements)

References 245 publications

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“…The great majority of nociceptive primary sensory neurons express the transient receptor potential cation channel sub-family V member 1 ion channel (TRPV1) that is pivotal in signalling, to the central nervous system, inflammatory events in peripheral tissues that quickly develop following burn injury20232425. Therefore, we studied the relationship of TRPV1-expressing spinal terminals of nociceptive primary sensory neurons and SSDHN exhibiting p -S10H3 expression in the nucleus (Fig.…”

Section: Resultsmentioning

confidence: 99%

Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain

Torres-Pérez

Stella

Varga

et al. 2017

Sci Rep

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Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the development and maintenance of prolonged pain. Epigenetic mechanisms including post-translational modifications in histones are pivotal in regulating transcription. Here, we report that phosphorylation of serine 10 (S10) in histone 3 (H3) specifically occurs in a group of rat SSDHN following the activation of nociceptive primary sensory neurons by burn injury, capsaicin application or sustained electrical activation of nociceptive primary sensory nerve fibres. In contrast, brief thermal or mechanical nociceptive stimuli, which fail to induce tissue injury or inflammation, do not produce the same effect. Blocking N-methyl-D-aspartate receptors or activation of extracellular signal-regulated kinases 1 and 2, or blocking or deleting the mitogen- and stress-activated kinases 1 and 2 (MSK1/2), which phosphorylate S10 in H3, inhibit up-regulation in phosphorylated S10 in H3 (p-S10H3) as well as fos transcription, a down-stream effect of p-S10H3. Deleting MSK1/2 also inhibits the development of carrageenan-induced inflammatory heat hyperalgesia in mice. We propose that p-S10H3 is a novel marker for nociceptive processing in SSDHN with high relevance to transcriptional changes and the development of prolonged pain.

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Section: Resultsmentioning

confidence: 99%

Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain

Torres-Pérez

Stella

Varga

et al. 2017

Sci Rep

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“…TRPV1, the capsaicin receptor, is located on a large subset of nociceptors and plays important roles in sensory transduction and primary afferent sensitization. This channel can be activated in numerous ways, including by various exogenous vanilloid chemicals (e.g., capsaicin, resiniferatoxin) as well as by protons, heat greater than 42°C, and diverse endogenous lipid signals associated with inflammation [46]. Predictably, the sensation evoked by these stimuli when applied to skin is perceived by humans as a burning sensation [47]; but surprisingly is perceived as deep aching pain following intramuscular administration [48,49].…”

Section: Neuronal Alterations Associated With Cipnmentioning

confidence: 99%

Mechanisms Involved in the Development of Chemotherapy-Induced Neuropathy

2015

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SUMMARY Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and painful condition seen in patients undergoing treatment with common agents such as vincristine, paclitaxel, oxaliplatin and bortezomib. The mechanisms of this condition are diverse, and include an array of molecular and cellular contributions. Current research implicates genetic predispositions to this condition, which then may influence cellular responses to chemotherapy. Processes found to be influenced during CIPN include increased expression of inflammatory mediators, primarily cytokines, which can create cascading effects in neurons and glia. Changes in ion channels and neurotransmission, as well as changes in intracellular signaling and structures have been implicated in CIPN. This review explores these issues and suggests considerations for future research.

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“…Among physical factors, the most important for organism's homeostasis are stimulation of those receptors by high temperature (higher than 43°C), low pH values and the presence of other cations as well as endogenous vanilloids including 15-hydroperoxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid (15(S)-HPETE) produced by lipoxygenase [20][21][22][23].…”

Section: Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Health-promoting properties of compounds derived from Capsicum sp. A review

Szydełko

Boguszewska-Czubara

2017

Herba Polonica

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S u m m a r yThis article presents multidirectional effects of capsaicin and its natural derivatives as well as natural and synthetic analogs in term of their therapeutic properties. Active agents present in various Capsicum genus plants exert analgesic, anti-inflammatory, antibacterial, antioxidant and gastroprotective effects. Furthermore, capsaicin positively influences the metabolism of lipids. Numerous research show that capsaicinoids inhibit proliferation and migration process of cancer cells, what makes them molecules of high interest in oncology. Among broad range of positive activities, we have focused only on those properties that have already found application in medicine or seemed to be the most probably used in the near future. Even if in low or single doses this compound has been reported successful in numerous therapies, the negative consequences of high doses or prolonged administration is also discussed in the review.

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Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type-1 Ion Channel

Cited by 44 publications

References 245 publications

Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain

Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain

Mechanisms Involved in the Development of Chemotherapy-Induced Neuropathy

Health-promoting properties of compounds derived from Capsicum sp. A review

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