Pharmacology, phytochemistry, and traditional uses of Scrophularia ningpoensis Hemsl

Ren, Dunqiang; Shen, Zhan-Yun; Qin, Lu‐Ping; Zhu, Bo

doi:10.1016/j.jep.2020.113688

Cited by 32 publications

(23 citation statements)

References 49 publications

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“…The main bioactive constituents in Schizonepeta tenuifolia are four monoterpenes, (−)-menthone, (+)-pulegone, (−)-limonene and (+)-menthofuran; the plant also contains other compounds such as 1-octen-3-ol, 3-octanone, β-myrcene, and β-caryophyllene [ 23 ]. Scrophularia ningpoensis contains over 162 compounds including iridoids and iridoid glycosides, phenylpropanoid glycosides, organic acids, terpenoids, saccharides, flavonoids, sterols, and saponins [ 24 ]. Prunus armeniaca contains phenolic and cyanogenic compounds and pectin polysaccharides [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

Hetrick

Yu²,

Olanrewaju

et al. 2021

Cell Biosci

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Background The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduce mortality. We investigated the potential anti-coronavirus activities from an oral liquid of traditional medicine, Respiratory Detox Shot (RDS), which contains mostly herbal ingredients traditionally used to manage lung diseases. Results Here we report that RDS inhibited the infection of target cells by lenti-SARS-CoV, lenti-SARS-CoV-2, and hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudoviruses, and by infectious SARS-CoV-2 and derived Ha-CoV-2 variants including B.1.1.7, B.1.351, P.1, B.1.429, B.1.2, B.1.494, B.1.1.207, B.1.258, and B.1.1.298. We further demonstrated that RDS directly inactivates the infectivity of SARS-CoV-2 virus particles. In addition, we found that RDS can also block the infection of target cells by Influenza A virus. Conclusions These results suggest that RDS may broadly inhibit the infection of respiratory viruses.

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Section: Resultsmentioning

confidence: 99%

A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

Hetrick

Yu²,

Olanrewaju

et al. 2021

Cell Biosci

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“…FDFT1 catalyzes a two‐step reaction in which two molecules of farnesyl diphosphate are converted into one molecule of squalene. β‐Sitosterol and β‐daucosterol are the main sterols in the roots of S. ningpoensis 75 . The conversion of 24‐methylenelophenol to 24‐ethylidenelophenol was catalyzed by SMT2.…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomic analysis reveals novel insights into the continuous cropping induced response inScrophularia ningpoensis

Sun

et al. 2022

J Sci Food Agric

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BACKGROUND Scrophularia ningpoensis is a well‐known medicinal crop. Continuous cropping seriously affects the yield and quality, but little is known about the influence of continuous cropping on metabolic pathways. In this study, the difference in protein abundance between continuous cropping and non‐continuous cropping of S. ningpoensis roots was studied by proteomics, and the molecular mechanism that protects S. ningpoensis against continuous cropping was explored. RESULTS The results suggested that continuous cropping in S, ningpoensis altered the expression of proteins related to starch and sucrose metabolism, glycolysis/gluconeogenesis, pentose phosphate pathway, citric acid cycle, phenylalanine, tyrosine and tryptophan biosynthesis, phenylpropanoid biosynthesis, terpenoid backbone biosynthesis, monoterpenoid biosynthesis, sesquiterpenoid and triterpenoid biosynthesis, and steroid biosynthesis. Among these processes, the most affected were phenylpropanoid biosynthesis and starch and sucrose metabolism, which may be important for continuous cropping resistance. CONCLUSION The effect of continuous cropping on S. ningpoensis was demonstrated at the proteome level in this work, and identified candidate proteins that may cause continuous cropping reactions. The paper provides the theoretical foundation and scientific reference for enhancing the continuous cropping resistance of S. ningpoensis. © 2022 Society of Chemical Industry.

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“…Based on a network pharmacology study, QWBD was found to exert antisepsis actions by regulating protein phosphorylation, the cell response to cytokine stimulation, cell proliferation, the inflammatory response, the transmembrane receptor protein tyrosine kinase signaling pathway, and cytokine-mediated signaling pathways [201]. Although the phytochemistry of the component herbs Dihuang [202], Xijiao [203], Huanglian [204], Zhizi [121,205], Jiegeng [206], Huangqin [207], Zhimu [208], Chishao [209], Xuanshen [210], Lianqiao [211], Danzhuye [212], Gancao [213], Danpi [214], and Shigao (CaSO 4 •2H 2 O) have been widely reported, chemical composition studies of QWBD are limited. A total of 21 compounds from 11 component herbs were detected in QWBD and characterized, among which 15 analytical markers were selected for the quality evaluation of QWBD: baicalin (content level, 563.1-852.8 µg/g or 1.26-1.91 µmol/g), wogonoside (64.9-106.8 µg/g or 0.14-0.23 µmol/g), geniposidic acid (10.1-21.1 µg/g or 0.03-0.06 µmol/g), oxypaeoniflorin (18.2-25.3 µg/g or 0.04-0.05 µmol/g), genipin 1-β-D-gentiobioside (25.7-60.7 µg/g or 0.047-0.11 µmol/g), geniposide (131.9-396.7 µg/g or 0.34-1.02 µmol/g), paeoniflorin (201.2-305.5 µg/g or 0.42-0.64 µmol/g), mangiferin (50.6-79.2 µg/g or 0.12-0.19 µmol/g), swertiajaponin (17.9-58.7 µg/g or 0.037-0.12 µmol/g), acteoside (106.8-143.8 µg/g or 0.17-0.23 µmol/g), forsythoside A (124.2-261.6 µg/g or 0.20-0.42 µmol/g), berberine hydrochloride (156.2-654.1 µg/g or 0.42-1.76 µmol/g), paeonol (6.24-18.5 µg/g or 0.038-0.11 µmol/g), harpagoside (3.21-14.1 µg/g or 0.006-0.029 µmol/g), and glycyrrhizic acid (46.9-14.1 µg/g or 0.057-0.16 µmol/g).…”

Section: Qingwen Baidu Decoctionmentioning

confidence: 99%

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on the timely and appropriate administration of antimicrobials and supportive therapies, but the search for pharmacotherapies modulating the host response has been unsuccessful. Chinese herbal medicines, i.e., Chinese patent medicines, Chinese herbal prescriptions, and single Chinese herbs, play an important role in the treatment of sepsis through multicomponent, multipathway, and multitargeting abilities and have been officially recommended for the management of COVID-19. Chinese herbal medicines have therapeutic actions promising for the treatment of sepsis; basic scientific research on these medicines is increasing. However, the material bases of most Chinese herbal medicines and their underlying mechanisms of action have not yet been fully elucidated. This review summarizes the current studies of Chinese herbal medicines used for the treatment of sepsis in terms of clinical efficacy and safety, pharmacological activity, phytochemistry, bioactive constituents, mechanisms of action, and pharmacokinetics, to provide an important foundation for clarifying the pathogenesis of sepsis and developing novel antisepsis drugs based on Chinese herbal medicines.

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Pharmacology, phytochemistry, and traditional uses of Scrophularia ningpoensis Hemsl

Cited by 32 publications

References 49 publications

A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

Comparative proteomic analysis reveals novel insights into the continuous cropping induced response inScrophularia ningpoensis

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

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