Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders

Choi, Jin Gyu; Kim, Sun Yeou; Jeong, Minsun; Oh, Myung Sook

doi:10.1016/j.pharmthera.2017.08.010

Cited by 118 publications

(82 citation statements)

References 157 publications

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“…It has been used to treat diseases in China for more than 2000 years. 6-Gingerols (6G), which is a phenolic ingredient purified from ginger, has been reported to exert anti-inflammation, anti-oxidative and anti-apoptotic roles [5][6][7]. 6G is reported to alleviate myocardial ischemia/reperfusion injury [8].…”

Section: Introductionmentioning

confidence: 99%

6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3

Kang

Han

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) 6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3, Artificial ABSTRACT Finding novel therapeutic agent for the treatment of cerebral ischemia is urgently required. These experiments explored the potential roles of 6-Gingerols (6G) in hypoxia-stimulated rat PC-12 cells. Cell viability, apoptosis and its related proteins were studied by the approaches of MTT assay, flow cytometry assay and Western blot analysis, respectively. In addition, whether 6G achieved its functions in hypoxia-induced injury through miR-103 was illustrated. Moreover, the associated signalling pathways were investigated. Obviously, hypoxia treatment blocked cell viability and enhanced apoptosis while this trend was ameliorated by 6G. Then we observed that hypoxia administration up-regulated miR-103 expression and 6G could further increase miR-103 expression in hypoxia-stimulated PC-12 cells. Inhibition of miR-103 attenuated the neuroprotective effects of 6G on hypoxia-treated PC-12 cells. Moreover, Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) was a target of miR-103 and BNIP3 upregulation also attenuated the neuroprotective impact of 6G on hypoxia-treated PC-12 cells. Hypoxia activated the p38MAPK and JNK pathways were inactivated by 6G. To sum up, 6G protected hypoxiastimulated PC-12 cells through miR-103-mediatated down-regulation of BNIP3 by inhibiting p38 MAPK and JNK pathways. HIGHLIGHTS 1. 6-Gingerols (6G) is a promising agent for cerebral ischemia therapy. 2. The neuroprotective effects of 6G are mediated by miR-103 and BNIP3. 3. Up-regulation of miR-103 exerts neuroprotective effects. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3

Kang

Han

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…It has been used for the treatment of diseases for more than 2000 years in China. Gingerol is a phenolic material in ginger, and 6-gingerol (6-G) is its main ingredient that has marked anti-inflammatory, antioxidative, and antiapoptotic roles [ 14 – 16 ]. Recent studies showed that 6-G could reduce the levels of inflammatory markers, TNF- α , IL-6, and IL-1 β , representing a potential strategy for the treatment of atherosclerosis [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

6‐Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt‐Dependent Mechanism in Rats

Qin

Jiang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Our previous study has demonstrated that 6-Gingerol (6-G) could alleviate myocardial ischemia/reperfusion injury (MIRI). However, the molecular mechanism underlying the process of myocardial ischemia/reperfusion (I/R) injury alleviation by 6-G remains unelucidated. The objective of the present study is to further investigate the potential mechanism for 6-G to alleviate MIRI in rats. Thirty-two Sprague-Dawley rats were randomly divided into four groups: the Sham group, the I/R group, the 6-G + I/R group, and the LY294002 (LY) + 6-G + I/R group. For the rats in each of the groups, data were collected for cardiogram, cardiac function, area of myocardial infarction, myocardial pathology, myocardial enzyme, marker of inflammatory response, and PI3K/Akt signaling pathway. We found that the pretreatment of 6-G with 6 mg/kg could shrink the ST section of cardiogram, improve the cardiac function, reduce the area of myocardial infarction and the degree of cardiac pathological injury, lower the level of myocardial enzyme, and inhibit the inflammatory response. In addition, our results also indicated that 6-G could upregulate the expression of PI3K and p-Akt and that LY294002, a blocking agent of PI3K/Akt signaling pathway, could nullify the protecting role of 6-G. Our experimental results showed that 6-G could inhibit I/R-induced inflammatory response through the activation of the PI3K/Akt signaling pathway.

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“…In recent years, other industries have started to use Schizosaccharomyces species in products and processes other than the production of grape wine, such as ginger fermentation [106,107], apple wine [108], kei-apple fermentation [109], sparkling wine [110], bioethanol [111], bilberry fermentation [71], plum wine [112], and water purification [18].…”

Section: Schizosaccharomyces Speciesmentioning

confidence: 99%

The Influence of Non-Saccharomyces Species on Wine Fermentation Quality Parameters

2019

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In the past, some microbiological studies have considered most non-Saccharomyces species to be undesirable spoilage microorganisms. For several decades, that belief made the Saccharomyces genus the only option considered by winemakers for achieving the best possible wine quality. Nevertheless, in recent decades, some strains of non-Saccharomyces species have been proven to improve the quality of wine. Non-Saccharomyces species can positively influence quality parameters such as aroma, acidity, color, and food safety. These quality improvements allow winemakers to produce innovative and differentiated wines. For that reason, the yeast strains Torulaspora delbrueckii, Lachancea thermotolerans, Metschnikowia pulcherrima, Schizosaccharomyces pombe, and Pichia kluyveri are now available on the market. Other interesting species, such as Starmerella bacillaris, Meyerozyma guilliermondii, Hanseniospora spp., and others, will probably be available in the near future.

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Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders

Cited by 118 publications

References 157 publications

6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3

6-Gingerols (6G) reduces hypoxia-induced PC-12 cells apoptosis and autophagy through regulation of miR-103/BNIP3

6‐Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt‐Dependent Mechanism in Rats

The Influence of Non-Saccharomyces Species on Wine Fermentation Quality Parameters

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