Pharmacotherapy of Type 2 Diabetes Mellitus

Rendell, Marc; Kirchain, William R.

doi:10.1345/aph.19171

Cited by 24 publications

(15 citation statements)

References 196 publications

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“…Thus, exercise, weight loss and health lifestyle can make improvements in the disease state and for some patients reduce clinical symptoms (Simpson, Shaw, & Zimmet, 2003). Unlike T1DM, certain type 2 pharmacotherapies are useful in boosting insulin sensitivity as well as increasing production of β-cell insulin (Rendell & Kirchain, 2000).…”

Section: Type 2 Diabetes (T2dm)mentioning

confidence: 99%

The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines

Adams

Imran

Wang

et al. 2011

Food Research International

145

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Section: Type 2 Diabetes (T2dm)mentioning

confidence: 99%

The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines

Adams

Imran

Wang

et al. 2011

Food Research International

145

View full text Add to dashboard Cite

“…Thiazolinediones (TZDs), the PPAR γ agonists, have been demonstrated by a number of clinical trials in the management of insulin resistance and type 2 diabetes [6–8]. However, these agonists can also produce moderate to serious side effects such as edema, weight gain, congestive heart failure, and hepatotoxicity [9, 10]. Thus, the development of drugs of dual or pan PPAR modulators with less side effects is desirable for the management of obesity-related diabetes and dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator‐Activated Receptors

et al. 2008

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Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARγ and α, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form. In vitro studies demonstrate that cinnamon increases the expression of peroxisome proliferator-activated receptors γ and α (PPARγ/α) and their target genes such as LPL, CD36, GLUT4, and ACO in 3T3-L1 adipocyte. The transactivities of both full length and ligand-binding domain (LBD) of PPARγ and PPARα are activated by cinnamon as evidenced by reporter gene assays. These data suggest that cinnamon in its water extract form can act as a dual activator of PPARγ and α, and may be an alternative to PPARγ activator in managing obesity-related diabetes and hyperlipidemia.

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“…Phenformin is a biguanide compound used for the management of patients with diabetes (Bailey, 1992;Rendell and Kirchain, 2000). Its use has been limited in the last two decades because of an association with lactic acidosis.…”

Section: Introductionmentioning

confidence: 99%