Pharmacotherapy to Improve the Acquired Aphasia following Brain Damages: A Review Study

Abstract

Background & Aim: Using pharmaceutical agents in treatment of aphasia has caught the attention of many neurologists and neuroscientists. This short review study has sought the role of pharmacotherapy in treatment of aphasia, a linguistic impairment after acquired brain lesions. The pharmacological principles and mechanisms related to the effects of drugs used in aphasia rehabilitation are pointed. Then, some evidence of clinical trials on different drugs in this field is presented. Methods & Materials/Patients:A comprehensive search in databases including MEDLINE, Cochrane, PubMed, Scopus, EMBASE, Science Direct on experimental studies and clinical trials associated with pharmacotherapy of aphasia after neurological damages was performed.

Supporting Post-Stroke Language and Cognition with Pharmacotherapy: Tools for Each Phase of Care

“…This has led to numerous lines of research into augmenting the effectiveness and efficiency of SLT hours, notably via neurostimulation [7][8][9][10][11] or pharmacological adjuncts [12,13]. Enthusiasm among clinicians and patients alike for a "magic pill" to reverse ischemic brain injury's effects has been reflected in reviews on the topic of pharmacology in aphasia [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], recently emerging at the rate of about one per year. Notably, the rate of reviews well exceeds that of clinical trials, positive or otherwise.…”