Pharmakologische Wirkungen am isolierten Ganglien-Muskelpr�parat des Gelbrandk�fers

Actions on Insects and Other Invertebrates

“…of the synaptic effects in insects, other than those of the initial after-discharge and block, indicates that the conditions designated as "synchronized synaptic response" and "continuous block" cannot be consequences of "irreversible" inhibition of ChE by the organophosphorus agents employed. With reversible inhibitors, such as physostigmine, washing restores the preparation to a completely normal condition, except that there is a tendency for it to be refractory to further doses of the agent (v. KRUPP et al 1952). Such restoration to wholly normal transmission is not possible with organophosphorus compounds.…”