Phase 2 Trial of Accelerated Partial Breast Irradiation (APBI) Using Noninvasive Image Guided Breast Brachytherapy (NIBB)

Hepel, Jaroslaw T.; Leonard, Kara L.; Sha, Sandra; Graves, Theresa A.; Wiggins, Doreen L.; Mastras, Dean; Pittier, Ann; Wazer, David E.

doi:10.1016/j.ijrobp.2020.07.2312

Cited by 10 publications

(4 citation statements)

References 35 publications

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“…After results of studies with long term follow up, this technique was accepted in experienced centers as comparable to WBI in terms of efficacy and toxicity [9,10]. Furthermore, there is a novel approach to delivery of APBI-image guided breast brachytherapy that maintains a high level of precision by using breast immobilization via breast compression and image guidance [11].…”

Section: Discussionmentioning

confidence: 99%

Implementation of accelerated partial breast irradiation at the Oncology Institute of Vojvodina

et al. 2022

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Introduction. Early breast cancer is usually treated with breast conserving surgery followed by radiation treatment. Whole breast irradiation is standard of care so far, but currently there is an increasement in accelerated partial breast irradiation for selected patients which showed many advantages. The aim of this paper is to present the implementation of the accelerated partial breast irradiation in Oncology Institute of Vojvodina. Case outline. A 54-year-old woman was referred to radiotherapy after breast conserving surgery. After she met all of the inclusion criteria, she underwent accelerated partial breast irradiation with 38.5 Gy in 10 fractions. Active breathing control device was used during the treatment and cone beam computed tomography was performed before each fraction for purpose of target position control. She terminated therapy in good health condition with only adverse effect of mild radiation dermatitis of irradiated area. On the first follow up, she was without any symptom or sign of disease or complication. Conclusion. Accelerated partial breast irradiation is safe and effective. Radiation oncologist should be encouraged to implement this technique.

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Section: Discussionmentioning

confidence: 99%

Implementation of accelerated partial breast irradiation at the Oncology Institute of Vojvodina

et al. 2022

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“…The good cosmetic effect at 5 years reached 100%. The 5-year IBTR was only 6.7%, and 5-year OS was 93.7% ( 74 ). NIBB had a low incidence of late toxicity and good cosmetic appearance, which needs to be verified by a larger cohort.…”

Section: Short-range Radiation Therapy Techniques After Breast-conser...mentioning

confidence: 99%

Recent advances progress in radiotherapy for breast cancer after breast-conserving surgery: a review

Wang,

Shen,

et al. 2023

Front. Oncol.

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Adjuvant radiotherapy after breast-conserving surgery has become an integral part of the treatment of breast cancer. In recent years, the development of radiotherapy technology has made great progress in this field, including the comparison of the curative effects of various radiotherapy techniques and the performance of the segmentation times. The choice of radiotherapy technology needs to be co-determined by clinical evidence practice and evaluated for each individual patient to achieve precision radiotherapy. This article discusses the treatment effects of different radiotherapy, techniques, the risk of second cancers and short-range radiation therapy techniques after breast-conserving surgery such as hypo fractionated whole breast irradiation and accelerated partial breast irradiation. The choice of radiotherapy regimen needs to be based on the individual condition of the patient, and the general principle is to focus on the target area and reduce the irradiation of the normal tissues and organs. Short-range radiotherapy and hypofractionated are superior to conventional radiotherapy and are expected to become the mainstream treatment after breast-conserving surgery.

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“…96 Noninvasive breast brachytherapy is a new technique and was initially evaluated in a small study with promising outcomes with short-term follow-up; further follow-up demonstrated the technique was well tolerated, though longer follow-up is needed to assess local control. 97,98 An additional novel brachytherapy technique is the use of peri-operative brachytherapy. With this approach, patients undergo CT planning after BCS with delivery of a single fraction of HDR brachytherapy.…”

Section: Ultrashort Partial Breast Irradiationmentioning

confidence: 99%

Delivery of Adjuvant Radiation in 5 Days or Less After Lumpectomy for Breast Cancer: A Systematic Review

Vicini

Broughman

Halima

et al. 2022

International Journal of Radiation Oncology*Biology*Physics

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Phase 2 Trial of Accelerated Partial Breast Irradiation (APBI) Using Noninvasive Image Guided Breast Brachytherapy (NIBB)

Cited by 10 publications

References 35 publications

Implementation of accelerated partial breast irradiation at the Oncology Institute of Vojvodina

Implementation of accelerated partial breast irradiation at the Oncology Institute of Vojvodina

Recent advances progress in radiotherapy for breast cancer after breast-conserving surgery: a review

Delivery of Adjuvant Radiation in 5 Days or Less After Lumpectomy for Breast Cancer: A Systematic Review

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