An experimental investigation is conducted to study the effect of middle length and inclination angle of an S-shaped channel on adiabatic two-phase flow patterns. To study this effect, three channel lengths of 0.25, 0.50, and 1.00 m, and four bends at the angles of 22.5˚, 45˚, A dimensionless analysis of obtained flow pattern maps is also carried out. It is shown that effect of geometry changes along S-shaped pipeline on two-phase flow pattern transitions is determined by either inclination angle or elevation difference between two horizontal lines. The explained flow mechanisms, obtained flow pattern maps and the transition lines can be used to predict the particular flow pattern that will be established for a given mass flux, inclined length and angle along pipelines.