Phase behaviour of methylcellulose–poly(acrylic acid) blends and preparation of related hydrophilic films

Khutoryanskiy, Vitaliy V.; Cascone, Maria Grazia; Lazzeri, Luigi; Nurkeeva, Zauresh S.; Mun, Grigoriy A.; Mangazbaeva, Rauash A

doi:10.1002/pi.1004

Cited by 36 publications

(44 citation statements)

References 21 publications

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“…The cross-linked films can be prepared even by thermal treatment at 80 8C and 100 8C, which is probably due to the occurrence of an intermacromolecular esterification reaction between carboxylic groups of PMVEMAc and hydroxyl groups of HEC. Similar thermal cross-linking has been reported for the blends of poly(acrylic acid) with methylcellulose, [14] hydroxyethylcellulose, [26] and poly(2-hydroxyethyl vinyl ether). [27] The variation in temperature as well as the thermal treatment time allows preparing the hydrogel films with the required degree of swelling characteristics.…”

Section: Swelling Of Thermally Cross-linked Filmssupporting

confidence: 79%

“…Specific interactions have also been reported in blends between poly(acrylic acid) (PAA) and various water-soluble polysaccharides. [3,[10][11][12][13][14][15] Complete miscibility as a rule is attributed to the strong intermacromolecular hydrogen bonding between the component polymers. Studies on blends of water-soluble polysaccharides and carboxylic acid copolymers containing the groups, which are not able to form hydrogen bonds, are quite limited.…”

Section: Introductionmentioning

confidence: 99%

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Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

Khutoryanskaya

Khutoryanskiy

Pethrick

2005

Macro Chemistry & Physics

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Summary: Hydrophilic polymeric films based on blends of hydroxyethylcellulose and maleic acid‐co‐methyl vinyl ether were produced by casting from aqueous solutions. The physicochemical properties of the blends have been assessed using Fourier transform infrared spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, dielectric spectroscopy, etc. The pristine films exhibit complete miscibility due to the formation of intermacromolecular hydrogen bonding. The thermal treatment of the blend films leads to cross‐linking via intermacromolecular esterification and anhydride formation. The cross‐linked materials are able to swell in water and their swelling degree can be easily controlled by temperature and thermal treatment time. The formation of the crosslinks is apparent in the dynamic properties of the blends as observed through the mechanical relaxation and dielectric relaxation spectra. The dielectric characteristics of the material are influenced by the effects of change in the local structure of the blend on the ionic conduction processes and the rate of dipolar relaxation. Separation of these processes is attempted using the dielectric modulus method. Significant deviations from a simple additive rule of mixing on the activation energy are observed consistent with hydrogen bonding and crosslinking of the matrix. This paper indicates a method for the creation of films with good mechanical and physical characteristics by exposing the blends to a relatively mild thermal treatment.

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Section: Swelling Of Thermally Cross-linked Filmssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

Khutoryanskaya

Khutoryanskiy

Pethrick

2005

Macro Chemistry & Physics

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“…[2,3] During the last few years the researcher's interest have been caught by the intermacromolecular associations between synthetic/natural polymers e.g., poly(acrylic acid) with methyl, hydroxyethyl or hydroxypropyl cellulose. [4][5][6][7][8][9][10] The ability of some copolymers of maleic acid with different co-monomers i.e., vinyl acetate, acrylic acid and styrene to form interpolymeric complexes with hydroxypropyl cellulose (HPC) was studied. [11] The investigation of the interpolymer complex (IPC) formation between a synthetic polymer and a biological macromolecule could be a stage further in macromolecular association studies both from theoretical and experimental point of view.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

Bumbu

Vasile²,

Eckelt

et al. 2004

Macro Chemistry & Physics

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Summary: The hydrogen bonding‐interpolymer association of hydroxypropyl cellulose (HPC) with maleic acid‐styrene (MAc‐S) copolymer has been investigated in dilute aqueous solution by viscometry, turbidimetry and potentiometry. At a mixing ratio between MAc‐S and HPC of 10:90, the solution exhibits a phase separation upon heating, while for other mixing ratio no phase separation could be detected. The stability of the interpolymer complex (IPC) increases as the temperature rises. The stoichiometry of the IPC, in mole units, was estimated as being MAc‐S:HPC = 5:2. The thermodynamic functions (enthalpy and entropy) of the complexation process have been determined.

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“…34 It is probably that the ester formation during the crosslinking reaction of PAA-KGM blends occurs only to a minor extent. So, it is possible that insoluble films would be made without chemical or physical crosslinking procedures, which has potential application in biomedicine field.…”

Section: Figurementioning

confidence: 99%

Characteristics of konjac glucomannan and poly(acrylic acid) blend films for controlled drug release

Huang

Xiao

2006

J of Applied Polymer Sci

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Novel polymer blend films composed of konjac glucomannan (KGM) and poly(acrylic acid) (PAA) were prepared by mixing the aqueous solution of both samples at a different weight ratio. Their structure and properties were studied by attenuated total reflection infrared spectroscopy (ATR-IR), wide angle X-ray diffraction (WAXD), thermo gravimetric analysis (TGA), scanning electron microscopy (SEM), tensile strength test, and equilibrium swelling test. The structure analysis indicated that there is a strong interaction between KGM and PAA, which result in a uniform structure and complete miscibility between the components. Potential applications of the polymer composed matrices in controlled drug delivery were also examined. The drug-loaded KGM/PAA composed matrices were prepared by coated films and directly compressed tablets, respectively. The release mechanism of a model drug, ketoprofen, from two matrices in phosphate buffer solution (pH ϭ 7.4) was studied. Release behavior of ketoprofen rely on preparation methods of matrices and the ratio of KGM to PAA in matrices. The result showed that the drug release from the coated films is Fickian diffusion mechanism. However, for tablets, the drug release is a non-Fickian kinetics process. Various delivery parameters have been calculated and the results are discussed.

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Phase behaviour of methylcellulose–poly(acrylic acid) blends and preparation of related hydrophilic films

Cited by 36 publications

References 21 publications

Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

Characterisation of Blends Based on Hydroxyethylcellulose and Maleic Acid‐alt‐Methyl Vinyl Ether

Investigation of the Interpolymer Complex between Hydroxypropyl Cellulose and Maleic Acid‐Styrene Copolymer, 1

Characteristics of konjac glucomannan and poly(acrylic acid) blend films for controlled drug release

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