Characteristics of konjac glucomannan and poly(acrylic acid) blend films for controlled drug release

Abstract

Novel polymer blend films composed of konjac glucomannan (KGM) and poly(acrylic acid) (PAA) were prepared by mixing the aqueous solution of both samples at a different weight ratio. Their structure and properties were studied by attenuated total reflection infrared spectroscopy (ATR-IR), wide angle X-ray diffraction (WAXD), thermo gravimetric analysis (TGA), scanning electron microscopy (SEM), tensile strength test, and equilibrium swelling test. The structure analysis indicated that there is a strong interaction between KGM and PAA, which result in a uniform structure and complete miscibility between the components. Potential applications of the polymer composed matrices in controlled drug delivery were also examined. The drug-loaded KGM/PAA composed matrices were prepared by coated films and directly compressed tablets, respectively. The release mechanism of a model drug, ketoprofen, from two matrices in phosphate buffer solution (pH ϭ 7.4) was studied. Release behavior of ketoprofen rely on preparation methods of matrices and the ratio of KGM to PAA in matrices. The result showed that the drug release from the coated films is Fickian diffusion mechanism. However, for tablets, the drug release is a non-Fickian kinetics process. Various delivery parameters have been calculated and the results are discussed.

Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly(aspartic acid) for in vitro drug delivery

“…Three bands observed at 1697, 1532 and 1257 cm À1 are due to amide-I, amide-II and amide-III, respectively (Zhao et al, 2006). KGM (b) shows the characteristic absorption peaks of the mannose appeared at 874 and 808 cm À1 (Yu et al, 2006). In the case of the semi-IPN hydrogel, all the peaks appeared both in PAsp and KGM were observed.…”

“…KGM is a high-molecular weight, watersoluble, non-ionic, natural polysaccharide isolated from the tubers of the amorphophallus konjac plants and the main crop in mountainous areas of China (Yu, Huang, & Xiao, 2006). It is mainly composed of a high-molecular weight glucomannan in which mannose and glucose units in a ratio of 1.6:1 are connected by b-(1,4) linkages (PéCrols et al,1997).…”

Adsorption–desorption properties and characterization of crosslinked Konjac glucomannan-graft-polyacrylamide-co-sodium xanthate

“…Moreover, with increased temperature, the maximum weight loss of most of the samples appears in the range of 210-370 • C, corresponding to the decomposition of samples. The experiment was carried out under similar conditions to the previous reports and results are homologous [25][26][27].…”

“…The XRD patterns of the neat KGM displays a typical broad hump located around 2Â = 20 • with ill-defined diffraction peaks, which indicates that the neat KGM is in the amorphous phase [25]. Several small and weak crystalline peaks at 15 • , 36 • , and 40 • , were assigned to a few Mannan II crystals of KGM glucomannan [26]. The broad hump at about 2Â = 20 • gradually split into two small separate humps with an increase of copper ion removal rate from 67% to 95%.…”

A thermal analysis method to predict the complete phase diagram of drug–polymer solid dispersions

“…(3): (Yu et al, 2006) Then, the spinodal phase separation curve (T s − ) can be calculated by equating the second derivative of the free energy to zero and expressed as (Eq. (4)):…”