Due to the improvement of living standards, people’s attention to health has gradually increased. More and more people are willing to spend money and time on health management. This article reviews work on the vital signs monitoring system based on fiber optic interferometers, including the design of sensor structures, signal demodulation methods and data analysis. After a large number of trials, the system can achieve long-term stable heart rate (HR), respiration rate (RR) and body temperature monitoring, and the collected data can be used for health analysis. Due to the high sensitivity, low cost, and light weight of the interferometric fiber optic sensor, it can be integrated under a mattress or a cushion, which is very suitable for daily use. The system has great application prospects in the field of healthcare.