Phase diagram for the mixtures of ibuprofen and stearic acid

Lerdkanchanaporn, Supaporn; Dollimore, D.; Evans, S.J.

doi:10.1016/s0040-6031(00)00656-0

Cited by 29 publications

(23 citation statements)

References 4 publications

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“…If a simple eutectic is formed, single blank line would be observed in the contact area when the temperature is raised (Davis et al, 2004). Result shown in Figure 1 indicates formation of eutectic, the simple one, between ibuprofen and stearic acid and confirms result of previously conducted experiment (Lerdkanchanaporn et al, 2001).…”

Section: Hot Stage Microscopy Studysupporting

confidence: 87%

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Physical Characterization of Ibuprofen-Stearic Acid Binary Mixture Due to Compression Force

Setyawan

Isadiartuti

Betari

et al. 2016

Indonesian J. Pharm.

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Section: Hot Stage Microscopy Studysupporting

confidence: 87%

“…Stearic acid is a tablet lubricant with melting point of 57.23C (Wang et al, 2010). Eutectic is known to be formed on ibuprofen-stearic acid binary mixture that is seen on phase diagram studied by Differential Scanning Calorimetric (DSC) (Lerdkanchanaporn et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Physical Characterization of Ibuprofen-Stearic Acid Binary Mixture Due to Compression Force

Setyawan

Isadiartuti

Betari

et al. 2016

Indonesian J. Pharm.

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“…Lerdkanchanaporn and coworkers [3,5] have studied evaporation process of ibuprofen in detail, and found its evaporation process is characteristic of a zero-order. And at any specified temperature, the rate of evaporation from a uniform surface will be a constant value for the zero-order process.…”

Section: The Results Of Tg and Thermodynamic Study For Ibuprofenmentioning

confidence: 99%

“….0 and 42.7-46.1 kJ mol −1 , respectively. Lerdkanchanaporn and coworkers [3][4][5] have studied thermal characteristics of mixtures of ibuprofen and/or starch/stearic acid by using simultaneous TG-DTA. Romero and Rhodes [6] have studied thermodynamic properties of ibuprofen enantiomers.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Sun

Tan

et al. 2004

Thermochimica Acta

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“…As a secondary analytical method, differential scanning calorimetry (DSC) provides an insight into the degree of interaction between drug and excipient (21,22). For example, the eutectic phase diagram for stearic acid and ibuprofen has been established, identifying two overlapping peaks for the melting temperatures (23). By combining dissolution and DSC data, it is possible to consider several factors that may influence the character of the resultant formulations, including the influence of these parameters on drug release.…”

Section: Introductionmentioning

confidence: 99%

Controlled Microwave Processing Applied to the Pharmaceutical Formulation of Ibuprofen

2011

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Abstract. The first successful development of controlled microwave processing for pharmaceutical formulations is presented and illustrated with a model drug (ibuprofen) and two excipients (stearic acid and polyvinylpyrrolidone). The necessary fine temperature control for formulation with microwave energy has been achieved using a uniquely modified microwave oven with direct temperature measurement and pulse-width modulation power control. In addition to comparing microwave and conventional heating, the effect of the presence of liquid (water) in aiding the mixing of the drug and excipient during formulation was also investigated. Analysis of the prepared formulations using differential scanning calorimetry and dissolution studies suggest that microwave and conventional heating produce similar products when applied to mixtures of ibuprofen and stearic acid. However, the differences were observed for the ibuprofen and polyvinylpyrrolidone formulation in terms of the dissolution kinetics. In all cases, the presence of water did not appear to influence the formulation to any appreciable degree. The application of controllable microwave heating is noteworthy as fine temperature control opens up opportunities for thermally sensitive materials for which microwave methods have not been feasible prior to this work.

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Phase diagram for the mixtures of ibuprofen and stearic acid

Cited by 29 publications

References 4 publications

Physical Characterization of Ibuprofen-Stearic Acid Binary Mixture Due to Compression Force

Physical Characterization of Ibuprofen-Stearic Acid Binary Mixture Due to Compression Force

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Controlled Microwave Processing Applied to the Pharmaceutical Formulation of Ibuprofen

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