It has been a real honor for me to organize this special issue which celebrates Prof. Brian Josephson's 80th birthday and his wonderful discovery [1, 2]. I am grateful to Sara Kate Heikerott, Senior Editor, and to Vladimir Kresin, Editor of the Journal of Superconductivity and Novel Magnetism, for the invitation. I am also grateful to all the authors for their contributions, and, especially, to John Clarke, who was playing an important role in the beginning of the project with his help with the content of the issue. It has been a real privilege for me to be in contact with such great and inspiring colleagues and friends. This issue obviously builds on the already available impressive literature including some dedicated volumes [3-8] and tries to give a flavor of the amazing impact of the Josephson effect in so many different fields of fundamental research and applications. I have been asked to give a short overview in view of a possible unitary vision over the various contributions. I would start from the contributions of John Clarke and John Rowell respectively. Apart from the scientific message, they are amazing historical documents. John Clarke in his "Brian Josephson and the Royal Society Mond Laboratory" brings us back to the autumn of 1964 in the Royal Society Mond Laboratory in Cambridge. We are at the Mond seminar of Brian Josephson, who is explaining his theory of pair tunneling in 1962 and its experimental demonstration by Anderson and Rowell during the following year, and finally observation of quantum interference by Jaklevic et al.-the introduction of the dc SQUID (Superconducting QUantum Interference Device). John's conclusions are a wonderful message not only for Brian Josephson but for every student looking for a project: "Looking back, it all started 56 years ago when I heard Brian Josephson's seminar and Brian Pippard's suggestion of the voltmeter the very next day. Brian, I offer my very best wishes and congratulations on