Phase equilibrium behaviors of chiral threonine: Phase diagrams, solubility, and thermodynamic model correlations

Xu, Jin; Xue, Yunna; Zhang, Qi; Zhang, Xiangyang

doi:10.1016/j.molliq.2023.123829

Journal of Molecular Liquids

2024

DOI: 10.1016/j.molliq.2023.123829

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Phase equilibrium behaviors of chiral threonine: Phase diagrams, solubility, and thermodynamic model correlations

Jin Xu,

Yunna Xue,

Qi Zhang

et al.

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Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

Sharma,

Park,

Garg

et al. 2024

J. Med. Chem.

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Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug's shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector. ■ SIGNIFICANCE• DES as solubility enhancer for API.• Drug delivery methods incorporating DES.• Recent developments in techniques using DES to improve API solubility. • Increasing stability of API with DES.• Different models and machine learning models analyzing DES for API solubility. • Future challenges with directions.

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Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

Sharma,

Park,

Garg

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

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Phase equilibrium behaviors of chiral threonine: Phase diagrams, solubility, and thermodynamic model correlations

Cited by 1 publication

References 62 publications

Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

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