“…Although biodegradation supposed to be an in vivo process, various in vitro simulations are widely investigated. However, to be closer to the in vivo conditions, the biodegradable assessments of CaPO 4 deposits are performed in various simulating solutions, such as SBF [158,159,289,794,[797][798][799][800][801][802][803][804], HBSS [236,788,805], aqueous saline solution [806,807], Ringer's solution [808,809], PBS [236,810,811], Eagle's minimum essential medium (EMEM) [812], etc. In addition, media containing osteoclast-like cells are used [813].…”