Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer

Bronchud, Miguel H.; Scarffe, J. H.; Thatcher, Nicholas; Crowther, Derek; Souza, Lawrence M.; Alton, N. K.; Testa, Nydia G; Dexter, T. M.

doi:10.1038/bjc.1987.295

Cited by 555 publications

(130 citation statements)

References 10 publications

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“…There were no appreciable changes in monocytes, eosinophils, platelets, lymphocytes or haemoglobin (Bronchud, et al, 1987).…”

Section: Resultsmentioning

confidence: 88%

“…We have shown previously (Bronchud et al, 1987) that the increase in peripheral neurophils was maintained for as long as the infusion of rhG-CSF continued, but the counts fell back to normal levels within 24 to 48 h after stopping the growth factor infusion. Table II shows that peripheral neutrophils after 3 days of rhG-CSF infusion were normal in tests of their mobility and phagocytic functions.…”

Section: Resultsmentioning

confidence: 99%

“…The study design has been described in our previous paper (Bronchud et al, 1987 Polymorph phagocytic function Phagocyte function was measured essentially as described by Easmon et al (1980) Ltd., 1988Br. J.…”

Section: Patientsmentioning

confidence: 99%

“…We have demonstrated the value of a colony-stimulating factor, rhG-CSF, in reducing the period of neutropenia (by a median of 80%) in patients treated with intensive chemotherapy, with a parallel protective effect against severe infections (Bronchud et al, 1987). In this study, twelve patients with small cell lung cancer received recombinant human granulocyte colony-stimulating factor (rhG-CSF) given by continuous infusion before the start -and after alternate cycles of intensive chemotherapy.…”

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confidence: 99%

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In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients

Bronchud

Potter²,

Morgenstern³

et al. 1988

Br J Cancer

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179

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Summary Twelve patients with small cell lung cancer were treated with recombinant human granulocyte colony-stimulating factor, rhG-CSF, given by continuous infusion at doses ranging from 1 to 40 ig kg-'day-'. Patients received the rhG-CSF before the start of intensive chemotherapy and after alternate cycles of chemotherapy. Several in vitro assays were performed using peripheral blood neutrophils and marrow progenitor cells collected from patients prior to and after infusion of the growth factor. Peripheral blood neutrophils were tested for mobility and phagocytic activity. In addition, in vitro clonogenic assays of marrow haemopoietic progenitor cells and analysis of bone marrow trephines and aspirates were carried out. We found that rhG-CSF in vivo has at least two main effects: (a) an early fall in peripheral neutrophils, within the first hour, followed by a rapid influx of mature neutrophils into the circulatory pool; (b) stimulation of proliferation and differentiation of neutrophil precursors in the bone marrow. Neutrophils released into the circulation were normal in tests of their mobility and phagocytic activity.

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“…There were no appreciable changes in monocytes, eosinophils, platelets, lymphocytes or haemoglobin (Bronchud, et al, 1987).…”

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients

Bronchud

Potter²,

Morgenstern³

et al. 1988

Br J Cancer

Self Cite

179

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show abstract

“…as a consequence. to introduce recombinant human granulocytecolony stimulating factor (rhG-CSF) for clinical use as a stimulator of granulopoiesis (2).…”

Section: Ip^roductionmentioning

confidence: 99%

In vivo effects of recombinant granulocyte‐colony stimulating factor in athymic nude mice

Pojda

Aoki

Tsuboi

1990

Immunology & Cell Biology

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SummaryThe possible role of T lymphocytes in in vivo regulation of haemopoiesis by recombinant human granulocyte‐colony stimulating factor (rhG‐CSF) was evaluated, Athymic nude (nu/nu) mice and their normal (+/+) littermates were injected subcutaneously twice daily with 100 μg/kg per day of rhG‐CSF for 5 days. Such parameters as number of neutrophils in blood, spleen weight and cellularity, bone marrow cellularity, and number of stem and progenitor cells (colony forming units in spleen [CFU‐S], mix colony forming cells [Mix‐CFC], granulocyte‐macrophage colony forming cells [GM‐CFC]) in bone marrow and spleen were evaluated. Some effects of the rhG‐CSF treatment were similar in nu/nu and +/+ mice. Others, however, were to some extent different in the two groups of animals. It is concluded that T lymphocytes may be partially responsible for some of the effects of rhG‐CSF in vivo activity.

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Neutropenia and Bacterial Infection in Acquired Immunodeficiency Syndrome

Moore

Keruly²,

Chaisson³

1995

Arch Intern Med

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Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer

Cited by 555 publications

References 10 publications

In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients

In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients

In vivo effects of recombinant granulocyte‐colony stimulating factor in athymic nude mice

Neutropenia and Bacterial Infection in Acquired Immunodeficiency Syndrome

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