Phase I study of daily cisplatin and concurrent radiotherapy in patients with cervical carcinoma

Daily Low-Dose Cisplatin-Based Concurrent Chemoradiotherapy in Patients With Uterine Cervical Cancer With Emphasis on Elderly Patients

“…12 In a phase 1 study including elderly patients, we had reported that 8 mg/m 2 per day is the recommended dosage for daily CCRT. Therefore, we conducted a phase 2 study to evaluate the efficacy and toxicity of daily CCRT for patients with locally advanced cervical cancer including those 70 years or older.…”

“…Previously, we had conducted a phase 1 study of cisplatin administered daily and concurrently with pelvic radiation (daily CCRT) to patients 75 years or younger and determined a recommended dosage of 8 mg/m 2 per day. 12 Here, we present the results of the phase 2 trial of daily CCRT, which evaluated the safety, durability, and treatment results in patients with stage IIA to IIIB cervical cancer, including patients older than 70 years.…”

Is a Low Dose of Concomitant Chemotherapy With Extended-Field Radiotherapy Acceptable as an Efficient Treatment for Cervical Cancer Patients With Metastases to the Para-Aortic Lymph Nodes?

“…Grade 3 to 4 leukopenia occurred in 50% and 58% of the 16 Japanese patients who received low-dose weekly cisplatin (20Y30 mg/m 2 ) and the 24 with high-dose weekly cisplatin (35Y40 mg/ m 2 ), respectively. 14 Mitsuhashi et al 16 administered a daily chemoradiotherapy regimen with the same mean dosage of cisplatin (168 mg/m 2 per patient) and found that 6 of 10 Japanese patients developed grade 3 to 4 leukopenia and/or neutropenia. The Japanese Gynecologic Oncology Group is currently conducting a prospective multi-institutional study for advanced cervical cancer patients that combine 40 mg/m 2 weekly cisplatin with pelvic radiotherapy to assess the acute and late morbidity.…”

Daily Low-Dose Cisplatin-Based Concurrent Chemoradiotherapy for the Treatment of Cervical Cancer in Patients 70 Years or Older

“…9,10 A total dose of 50 Gy was delivered in 25 daily fractions of 2 Gy, administered 5 days a week (Monday through Friday). Either low-(LDR) or high-dose-rate (HDR) intracavitary brachytherapy (ICBT) was applied for curative cases through external beam radiotherapy with central shielding.…”

“…9,10 This study evaluated safety, durability, and treatment results in patients with stage IIA-IIIB cervical cancer, including some patients 70 years or older. After this phase II study, daily CCRT could be an alternate choice of CCRT treatment in elderly patients; this regimen was selected as a clinical treatment for elderly patients with cervical cancer at our institution.…”