“…Pleiotropic drug-resistance has been reported for many different cell lines (Kaye & Merry, 1985). We tested, therefore, whether B16VDXR cells were sensitive to the cytotoxic action of other anthracyclines and of anticancer drugs having (Ferrari et al, 1984;Kaplan et al, 1984;Holdener et al, 1985), and 4'-deoxy-4'-iodio-DX, because it has been shown to be active on the DX-resistant P388 cell line (Facchinetti et al, 1984). VCR, a typical DX cross-resistant drug (Wilkoff & Dulmadge, 1978), and cis-DDP, a non DX crossresistant drug (Seeber et al, 1982), were also tested.…”