Phase II Study of Amrubicin in Patients with Refractory or Resistant Relapsed Small-Cell Lung Cancer: Japan Clinical Oncology Group Study (JCOG0901)

Daga, H.; Murakami, Hiroshi; Shibata, Tomohiro; Watanabe, Hiromi; Ichinose, Yukito; Yamamoto, Nobuyuki; Y, Ohe; Tamura, Tomoki

doi:10.1093/annonc/mds415

Cited by 2 publications

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“…Recent studies have indicated that antimesothelin immunotoxins, such as SS1P and RG7787, are well tolerated and exhibits significant antitumor activity in patients with MPM [33, 34]. Amatuximab is tolerable in MPM patients with a disease control rate of 90% when given with pemetrexed and cisplatin [35, 36]. The exposure of amatuximab is associated with overall survival, higher amatuximab exposure accompanied with longer overall survival [37].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

et al. 2017

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BackgroundSoluble mesothelin is beneficial to detect the progression and the treatment response of malignant pleural mesothelioma. However, the prognostic value of soluble mesothelin in malignant pleural mesothelioma remains unclear.MethodsHazard ratio with 95% CI was used to evaluate the prognostic value of soluble mesothelin and the effect of clinicopathological characteristics on the survival of malignant pleural mesothelioma.ResultsEight eligible studies involving 579 patients were selected for this meta-analysis. The results showed that soluble mesothelin level was significantly correlated with the survival of malignant pleural mesothelioma (pooled HR: 1.958, 95%CI: 1.531-2.504, p = 0.000; heterogeneity test: I2 = 1.1%, p = 0.421). In addition, the survival of malignant pleural mesothelioma was significantly correlated with some clinicopathological characteristics such as tumor histology (HR = 3.214, 95% CI = 2.071-4.988, p = 0.000; heterogeneity test: I2 = 0.0%, p = 0.623) and tumor stage (HR = 2.007; 95% CI = 1.477-2.727; p = 0.000; heterogeneity test: I2 = 0.0%, p = 0.966).ConclusionsThe survival of malignant pleural mesothelioma is significantly correlated with tumor histology and tumor stage. Furthermore, high soluble mesothelin level may lead to a poor prognosis for malignant pleural mesothelioma patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

et al. 2017

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Evaluation of serum-based cancer biomarkers: A brief review from a clinical and computational viewpoint

Yotsukura

Mamitsuka

2015

Critical Reviews in Oncology/Hematology

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Biomarkers are vital to detect diseases in various clinical stages. A variety of cancer serum biomarkers are already known, while for more accurate cancer-type detection, there required more rigorous evaluation manners, especially computational evaluation measures, for biomarkers. In this review, we first show three typical pitfalls in finding biomarkers and their examples, after briefly presenting standard five clinical biomarker screening phases by National Cancer Institute. We then introduce current computational biomarker evaluation measures, including current, standard methods with their intrinsic features. We further show an up-to-date list of existing cancer serum biomarkers, pointing out several issues, being caused by the limitations of current biomarker evaluation approaches. Finally we discuss the current attempts to develop new, statistically robust, computational serum-based biomarker measures in terms of specificity to each of various cancer types.

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Phase II Study of Amrubicin in Patients with Refractory or Resistant Relapsed Small-Cell Lung Cancer: Japan Clinical Oncology Group Study (JCOG0901)

Cited by 2 publications

References 0 publications

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis

Evaluation of serum-based cancer biomarkers: A brief review from a clinical and computational viewpoint

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