Phase II trial of titanocene dichloride in advanced renal-cell carcinoma

Lümmen, G.; Sperling, H.; Luboldt, Hans-Joachim; Otto, T.; Rübben, H.

doi:10.1007/s002800050838

Cited by 231 publications

(207 citation statements)

References 0 publications

Supporting

Mentioning

202

Contrasting

Order By: Relevance

“…This led to the development of alternative transition metal-based anticancer drugs (Farrell et al, 1999;Gelasco and Lippard, 1999;Jamieson and Lippard, 1999); however, success in this area has been slow. One such group, the metallocene dichlorides show remarkable antitumour activity Köpf, 1987, 1998); however, unfortunately, the efficacy of titanium dichloride (Cp 2 TiCl 2 ) in phase II clinical trials in patients with metastatic renal (Lummen et al, 1998) or breast cancer (Kröger et al, 2000) was too low to pursue. This highlights the requirement for additional agents in the treatment and management of human cancer.…”

mentioning

confidence: 99%

Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo

et al. 2007

View full text Add to dashboard Cite

Titanocene compounds are a novel series of agents that exhibit cytotoxic effects in a variety of human cancer cells in vitro and in vivo. In this study, the antiproliferative activity of two titanocenes (Titanocenes X and Y) was evaluated in human epidermoid cancer cells in vitro. Titanocenes X and Y induce apoptotic cell death in epidermoid cancer cells, with IC50 values that are comparable to cisplatin. Characterisation of the cell death pathway induced by titanocene compounds in A431 cells revealed that apoptosis is preceded by cell cycle arrest and the inhibition of cell proliferation. The induction of apoptosis is dependent on the activation of caspase-3 and -7 but not caspase-8. Furthermore, the antitumour activity of Titanocene Y was tested in an A431 xenograft model of epidermoid cancer. Results indicate that Titanocene Y significantly reduced the growth of A431 xenografts with an antitumour effect similar to cisplatin. These results suggest that titanocenes represent a novel series of promising antitumour agents.

show abstract

mentioning

confidence: 99%

Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Metallocene dichlorides (Cp2MCl2) with M = Ti, V, Nb and Mo show remarkable antitumor activity [33][34]. We are interested in studying titanium complexes in more detail, and investigating additional non-Cp-based systems.…”

Section: Introductionmentioning

confidence: 99%

Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes

et al. 2014

View full text Add to dashboard Cite

KEYWORDSTwo metal complexes of Ti(IV) were synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected from well known anticancer drugs. The ligands were prepared by the condensation of a mixture of sulfamethoxazole and the appropriate aldehyde namely, 3,4-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde. The structure of the ligands and their complexes were confirmed by spectroscopic data i.e. IR, 1 H NMR, electronic and elemental analysis. All compounds were screened for their in vitro anticancer potential using HELA and PC3 cells. All compounds showed limited cytotoxicity and complete cleavage of calf thymus deoxyribonucleic acid (CT-DNA).Titanium DNA studies Sulfamethoxazole Anti-cancer activity Schiff base complexes 3,4-Dimethoxybenzaldehyde

show abstract

“…Titanocene dichloride was also studied in phase I clinical trials in 1993 [50] and later in phase II clinical trials [51,52] and became very important in the field of antitumor metallodrugs. Although the results of phase II clinical trials were not satisfactory because of the lack of activity against the studied Further studies of the in vitro activity of 26 and 28 against 518A2 (melanoma), FaDu (head and neck carcinoma), HT-29 (colon cancer), MCF-7 (breast carcinoma), and SW1736 (thyroid cancer) cell lines showed the potent cytotoxic activity of 26 and 28 which induce apoptosis.…”

Section: Titanium-based Metallodrugsmentioning

confidence: 99%

“…Titanocene dichloride was also studied in phase I clinical trials in 1993 [50] and later in phase II clinical trials [51,52] and became very important in the field of antitumor metallodrugs. Although the results of phase II clinical trials were not satisfactory because of the lack of activity against the studied tumors, the excellent research on titanium compounds published by Tacke, Meléndez, McGowan, Baird, Valentine, and Tshuva, reignited the interest in novel titanium compounds with anticancer properties [53][54][55][56][57][58][59][60].…”

Section: Titanium-based Metallodrugsmentioning

confidence: 99%

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

2017

View full text Add to dashboard Cite

Abstract:For more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.

show abstract

Phase II trial of titanocene dichloride in advanced renal-cell carcinoma

Cited by 231 publications

References 0 publications

Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo

Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo

Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

Contact Info

Product

Resources

About