Phase III quality-of-life study results: impact on patients’ quality of life to reducing xerostomia after radiotherapy for head-and-neck cancer—RTOG 97-09

Fisher, J.; Scott, Charles; Scarantino, Charles W.; Leveque, Fran G; White, Robert L.; Rotman, Marvin; Hodson, D. Ian; Meredith, Ruby F.; Foote, Robert L.; Bachman, David G; Lee, Nancy

doi:10.1016/s0360-3016(03)00121-4

Cited by 84 publications

(64 citation statements)

References 6 publications

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“…The improvement of xerostomia may also be due to stimulation of residual function of non-irradiated parts of parotid and other salivary glands/ minor salivary glands. As consistent with our findings, some studies have also suggested that stimulation of these salivary glands by pilocarpine is responsible for better salivary gland function in irradiated patients [14][15][16].…”

Section: Discussionsupporting

confidence: 93%

Pilocarpine and Prevention of Radiation Induced Xerostomia in HNSCC

Atri¹

2014

JCPCR

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Section: Discussionsupporting

confidence: 93%

Pilocarpine and Prevention of Radiation Induced Xerostomia in HNSCC

Atri¹

2014

JCPCR

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“…Two prospective, randomized trials using pilocarpine to preserve salivary function have demonstrated that the QOL after RT for patients with head and neck cancer is independent of xerostomia. 34,35 Conversely, statistically significant correlations between xerostomia and QOL have been demonstrated in 2 longitudinal studies of IMRT-treated patients with head and neck cancer 30 and NPC. 36 Both studies indicated that patient-reported xerostomia decreased significantly, whereas QOL scores improved significantly over time during the first year after IMRT.…”

Section: Discussionmentioning

confidence: 99%

Intensity‐modulated or conformal radiotherapy improves the quality of life of patients with nasopharyngeal carcinoma

Fang

Tsai

Chen

et al. 2007

Cancer

100

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BACKGROUND.It was reported previously that the dosimetric superiority of conformal radiotherapy (RT), either 3‐dimensional conformal RT (3D‐CRT) or intensity‐modulated RT (IMRT), over conventional 2D‐RT translated into clinical benefits for patients with nasopharyngeal carcinoma (NPC). In this study, the authors compared quality‐of‐life (QOL) outcomes of NPC survivors who received treatment with 1 of 4 different RT techniques at a single institute during different periods.METHODS.The authors analyzed QOL data of from 237 patients with NPC who were cancer free for 2 or 3 years when their QOL was assessed. The study population included 152 patients who received conventional RT (2D‐RT, 61 patients; 2D‐RT plus 3D‐CRT boost, 91 patients) and 85 patients who received conformal RT (3D‐CRT, 33 patients; IMRT, 52 patients). The European Organization for the Research and Treatment of Cancer (EORTC) Core QOL questionnaire and the EORTC Head and Neck QOL questionnaire were completed.RESULTS.Compared with patients who received with conventional RT, patients who received conformal RT had both statistically (P < .05) and clinically (a difference in mean scores ≥10 points) significant improvements in the scales of global QOL, pain, appetite loss, senses, speech, social eating, teeth, opening mouth, xerostomia, sticky saliva, and feeling ill. No significant difference was observed in any of the scales that compared 2D‐RT with 2D‐RT plus 3D‐CRT boost or that compared 3D‐CRT with IMRT. Survivors who received conformal RT had a 2.01‐fold higher probability (odds ratio [OR], 2.01; 95% confidence interval [95% CI], 1.19–3.68) of reporting good global QOL and a 2.70‐fold lower probability (OR, 0.37; 95% CI, 0.20–0.66) of reporting a high level of xerostomia than survivors who received conventional RT.CONCLUSIONS.Conformal RT substantially improved head and neck‐related symptoms and broad aspects of QOL for survivors of NPC. Cancer 2007. © 2006 American Cancer Society.

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“…It affects the non-keratinized mucosa, soft palate, back of the tongue, floor of the mouth and oral cavity. Apart from the mucosal inflammation (10), there is a short fall in production of saliva due to the effect of radiation on the salivary glands (11). This results in great difficulty when chewing and swallowing food, with altered taste and local pain, leading to a decreased intake or even inability to eat.…”

Section: Effect Of a Specific Supplement Enriched With N-3 Polyunsatumentioning

confidence: 99%

Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients

et al. 2013

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Abstract. Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplement, on markers of inflammation, oxidative stress and metabolic status of ENT cancer patients undergoing radiotherapy (RT). Fourteen days after starting RT, 26 patients were randomly allocated to one of two groups, 13 supplemented with Prosure ® , an oncologic formula enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes (specific supplement), and 13 supplemented with Standard-Isosource ® (standard supplement). Patients were evaluated before RT, and 14, 28 and 90 days after starting RT. The results showed that there were no significant differences between the groups, but greater changes were observed in the standard supplement group, such as a decline in body mass index (BMI), reductions in hematocrit, erythrocyte, eosinophil and albumin levels, and a rise in creatinine and urea levels. We concluded that metabolic, inflammatory and oxidative stress parameters were altered during RT, and began to normalize at the end of the study. Patients supplemented with Prosure showed an earlier normalization of these parameters, with more favorable changes in oxidative stress markers and a more balanced evolution, although the difference was not significant.

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Phase III quality-of-life study results: impact on patients’ quality of life to reducing xerostomia after radiotherapy for head-and-neck cancer—RTOG 97-09

Cited by 84 publications

References 6 publications

Pilocarpine and Prevention of Radiation Induced Xerostomia in HNSCC

Pilocarpine and Prevention of Radiation Induced Xerostomia in HNSCC

Intensity‐modulated or conformal radiotherapy improves the quality of life of patients with nasopharyngeal carcinoma

Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients

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