Phase Resetting of the Mammalian Circadian Clock by DNA Damage

Oklejewicz, Małgorzata; Destici, Eugin; Tamanini, Filippo; Hut, Roelof A.; Janssens, Roel C.; Horst, Gijsbertus T. J. van der

doi:10.1016/j.cub.2008.01.047

Cited by 119 publications

(112 citation statements)

References 33 publications

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“…Several studies have demonstrated that external stimuli, such as ionizing radiation, UV light, and hydrogen peroxide affect circadian gene expression by cultured cells and tissues (34,35). We have also confirmed that hydrogen peroxide altered circadian gene expression and the accumulation of PER2 protein (supplemental Fig.…”

Section: Discussionsupporting

confidence: 80%

Involvement of Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in Regulation of Mammalian Circadian Clock

Uchida

Osaki

Yamasaki

et al. 2012

Journal of Biological Chemistry

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Background: MKK7 is a kinase involved in the cellular stress response. Results: MKK7 regulates circadian gene expression and the stability of an essential circadian component in unstressed mammalian cells. Conclusion: MKK7 functions as a circadian clock regulator. Significance: Our identification of role of MKK7 in the circadian clock provides insight into the importance of stress-responsive molecules in the maintenance of cellular homeostasis.

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Section: Discussionsupporting

confidence: 80%

Involvement of Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in Regulation of Mammalian Circadian Clock

Uchida

Osaki

Yamasaki

et al. 2012

Journal of Biological Chemistry

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“…Of the many processes being regulated by the circadian clock, some of the most profound are those related to specific cell-cycle events, DNA repair, and apoptosis (2,4,5,(21)(22)(23)(24)(25). The dynamics of the coupling we describe here are likely to be controlled through multiple and interacting pathways.…”

Section: Discussionmentioning

confidence: 97%

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

Feillet

Krusche

Tamanini

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Daily synchronous rhythms of cell division at the tissue or organism level are observed in many species and suggest that the circadian clock and cell cycle oscillators are coupled. For mammals, despite known mechanistic interactions, the effect of such coupling on clock and cell cycle progression, and hence its biological relevance, is not understood. In particular, we do not know how the temporal organization of cell division at the singlecell level produces this daily rhythm at the tissue level. Here we use multispectral imaging of single live cells, computational methods, and mathematical modeling to address this question in proliferating mouse fibroblasts. We show that in unsynchronized cells the cell cycle and circadian clock robustly phase lock each other in a 1:1 fashion so that in an expanding cell population the two oscillators oscillate in a synchronized way with a common frequency. Dexamethasone-induced synchronization reveals additional clock states. As well as the low-period phase-locked state there are distinct coexisting states with a significantly higher period clock. Cells transition to these states after dexamethasone synchronization. The temporal coordination of cell division by phase locking to the clock at a single-cell level has significant implications because disordered circadian function is increasingly being linked to the pathogenesis of many diseases, including cancer.coupled oscillators | oscillations | circadian rhythms | gating

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“…19,20) However, the physiological role of SCN-independent responses of peripheral clocks is not yet fully understood. A recent study has reported that DNA damage can also act as a resetting cue for the circadian clock in mammalian peripheral cells, 21) and other findings support a major role for the circadian machinery in cellular stress responses. 22) These data point to an intriguing link between the circadian clock and cellular stress responses, and it is the purpose of this review to summarize the evidence and explore the implications of such a link.…”

Section: Introductionmentioning

confidence: 92%

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Uchida

Hirayama

Nishina

2010

Biological & Pharmaceutical Bulletin

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INTRODUCTIONFrom bacteria to humans, almost all organisms can adapt the timing of their physiology to the cyclic changes of their environment, thanks to a naturally-selected intrinsic timekeeping system called the circadian clock. 1) The circadian clock enhances the physiological efficiency and survival of an organism by organizing its behavior and body functions. 2,3) During the circadian day, the organism's physiology is given over to catabolic processes, whereas the anabolic functions of growth, repair and consolidation occur at night. To achieve this schedule in mammals, the circadian clock regulates a number of physiological functions, including sleep and wakefulness, food intake, body temperature, cardiovascular and renal activity, hormone production, hepatic metabolism and immune responses. 4,5) Accordingly, disruption of the circadian clock in humans has been linked to profound effects on health, including insomnia, stomach ailments, depression and cancer. 4,5) In most organisms, the molecular mechanisms underlying the establishment and maintenance of biological rhythms comprise interconnected transcription-translation feedback loops in which some clock factors repress their own transcription once they have attained critical levels. 2,3) These oscillators have the property of being endogenous and cellautonomous systems that maintain their rhythm in the absence of external time cues. 6) Both vertebrates and invertebrates have circadian oscillators scattered throughout their bodies. 7,8) In mammals, the circadian system is composed of both central and peripheral oscillators. 7) The mammalian central clock is located in the suprachiasmatic nucleus (SCN) within the anterior hypothalamus of the brain. 9) This central clock acts as a coordinator and provides time signals via both neural and humoral routes that entrain independent peripheral clocks. Dysfunction of the central clock does not inactivate the peripheral clocks but instead causes individual peripheral oscillators to become temporally uncoupled. [10][11][12] To guarantee that an organism's behavior remains tied to the rhythms of its environment, the circadian clock must be able to reset itself in response to environmental cues. 9,13,14) The main environmental stimulus for organisms is light, which is provided in day-night cycles. Mammals have no photoreceptors in peripheral tissues, 15) so that the effect of light on peripheral clocks is indirect. 13) For the mammalian clock, the SCN integrates photic cues from the retina and uses neural and humoral signals to transmit this information to peripheral clocks, synchronizing them. [16][17][18] This communication between the central and peripheral clocks results in the seamless regulation of fundamental physiological functions. 4,8) Interestingly, peripheral clocks can also respond directly to SCN-independent signals such as feeding and temperature change. 19,20) However, the physiological role of SCN-independent responses of peripheral clocks is not yet fully understood. A recent study has reported that ...

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Phase Resetting of the Mammalian Circadian Clock by DNA Damage

Cited by 119 publications

References 33 publications

Involvement of Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in Regulation of Mammalian Circadian Clock

Involvement of Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in Regulation of Mammalian Circadian Clock

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

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