Phase Separation Phenomenon in Non-ionic Surfactant TX-114 Micellar Solutions: Effect of Added Surfactants and Polymers

Study of phospholipid-induced phase-separation in amphiphilic drugs

“…However, surfactants and some of the amphiphilic drugs can undergo phase separation under certain conditions [14][15][16][17]. The temperature at which this phase separation takes place is defined as Cloud Point (CP), which is a characteristic parameter of non ionic surfactants.…”

Investigations on microstructural changes in pH responsive mixed micelles of Triton X-100 and bile salt

“…The presence of NaDC (CMC ~ 6 mM) in mixed micelles and resultant increase in the charge density enhances aqueous solubility, as reflected in sharp increase in CP [4]. When the concentration of bile salt is increased above its CMC values, they start aggregating into micelles and their contribution to mixed micellization becomes less [60]. Viscosity results are equally quantified by decrease in D h of micelles obtained from DLS measurement (Fig.…”

“…With the addition of these bile salts to the existing nonionic TX-100 micelles, anionically charged mixed micelles are formed. Subsequently, the resultant charge repulsion between the head groups increases, which is reflected in an increase in the CP and decrease in solution viscosity [59,60]. With the addition of ionic component to existing nonionic micelles, the fractional contribution of the TX-100 species decreases, which should reflect in elevation of CP as the added bile salt will contribute to higher solubility of the mixed micelles.…”