Phase-shift, stimuli-responsive Drug Carriers for Targeted Delivery

O’Neill, Brian E.; Rapoport, Natalya

doi:10.4155/tde.11.81

Cited by 37 publications

(31 citation statements)

References 233 publications

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“…Fluorescence imaging of the bisected carotid artery and confocal fluorescence imaging of the frozen tissue sections have confirmed the enhanced drug delivery efficiency, as coincident with the previous report [20]. Such enhanced drug delivery efficiency is associated with a series of complicated mechanisms involving both ultrasound mediated fragmentation of MBs and the biological effects of ultrasound [31]. Ultrasound pulses may introduce acoustic cavitation of MBs and enhance the transient cell membrane permeability for drug delivery [32].…”

Section: Discussionsupporting

confidence: 80%

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Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Chang

Zhang

et al. 2016

Ultrasonics Sonochemistry

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We synthesized multifunctional activatible microbubbles (MAMs) for ultrasound mediated delivery of oxygen and drugs with both ultrasound and fluorescence imaging guidance. Oxygen enriched perfluorocarbon (PFC) compound was encapsulated in liposome microbubbles (MBs) by a modified emulsification process. DiI dye was loaded as a model drug. The ultrasound targeted microbubble destruction (UTMD) process was guided by both ultrasonography and fluorescence imaging modalities. The process was validated in both a dialysis membrane tube model and a porcine carotid artery model. Our experiment results show that the UTMD process effectively facilitates the controlled delivery of oxygen and drug at the disease site and that the MAM agent enables ultrasound and fluorescence imaging guidance of the UTMD process. The proposed MAM agent can be potentially used for UTMD-mediated combination therapy in hypoxic ovarian cancer.

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Section: Discussionsupporting

confidence: 80%

“…The droplet-to-bubble transition is accompanied with a dramatic increased droplet volume and a reduced shell thickness. This is expected to favor the release of the encapsulated drugs, especially under the condition that the ultrasound pulses rip off the drugs from the bubble surface [31].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Chang

Zhang

et al. 2016

Ultrasonics Sonochemistry

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“…39, 40 We also do not consider the cavitation of preexisting bubbles that is well studied elsewhere. 41 While NBs may have various sources of energy (the heating of liquid above the boiling threshold, local rarefaction, and plasma discharge), we employed an experimental model of a single NB in water.…”

mentioning

confidence: 99%

“…Due to the multiple biomedical applications of NBs and related phenomena, [34][35][36][37][38] it should be noted that we consider the transient events, but not the materials (particles) that are often also called nanobubbles. 39, 40 We also do not consider the cavitation of preexisting bubbles that is well studied elsewhere. 41 While NBs may have various sources of energy (the heating of liquid above the boiling threshold, local rarefaction, and plasma discharge), we employed an experimental model of a single NB in water.…”

mentioning

confidence: 99%

Experimental techniques for imaging and measuring transient vapor nanobubbles

Lukianova‐Hleb

Lapotko

2012

Applied Physics Letters

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Imaging and measuring transient vapor bubbles at nanoscale pose certain experimental challenges due to their reduced dimensions and lifetimes, especially in a single event experiment. Here, we analyze three techniques that employ optical scattering and acoustic detection in identifying and quantifying individual photothermally induced vapor nanobubbles (NBs) at a wide range of excitation energies. In optically transparent media, the best quantitative detection can be achieved by measuring the duration of the optical scattering time-response, while in an opaque media, the amplitude of the acoustic time-response well describes NBs in the absence of stress waves. Transient thermal evaporation and the generation of vapor bubbles are one of the basic processes accompanying non-stationary high-temperature heat-and mass-transfer in liquids. The science and the methods for the detection of inertial vapor bubbles of various origins were well developed for macro-and micro-sized bubbles and mainly employ their ability to emit pressure and to scatter the incident light. Recent developments in nanoscience reduced the spatial and temporal scale of vapor bubbles to nanometers and nanoseconds. [7][8][9][10]23,[27][28][29][30][31][32][33] Unlike their larger analogs, vapor nanobubbles (NBs) require much higher sensitivity and resolution of the detection methods for their imaging, quantification, and identification among other phenomena, such as transient heating and the generation of stress waves. Here, we analyze several experimental techniques for the imaging and quantitative analysis of transient vapor nanobubbles as single events and we troubleshoot some related errors. Due to the multiple biomedical applications of NBs and related phenomena, [34][35][36][37][38] it should be noted that we consider the transient events, but not the materials (particles) that are often also called nanobubbles.39, 40 We also do not consider the cavitation of preexisting bubbles that is well studied elsewhere. 41 While NBs may have various sources of energy (the heating of liquid above the boiling threshold, local rarefaction, and plasma discharge), we employed an experimental model of a single NB in water. Such a model provides maximal precision, control, and reproducibility in NB generation through the localized transient photothermal heating of liquid above the evaporation point. This was achieved through the optical excitation of individual 60 nm gold nanospheres in water with single short laser pulses (70 ps and 532 nm) at specific fluences above the NB generation threshold. We used the plasmonic conversion of optical energy into heat to control the maximal diameter and lifetime of the NBs through the fluence of a single laser pulse, as described in detail previously. [8][9][10]33 This experimental model includes an internal metal nanoparticle (NP) that acts as the source of the bubble energy during bubble generation and prevents the development of extreme temperatures and sonoluminescence at the collapse stage, 8,42 unlike "classical" bu...

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“…The drug (PTX) was tightly retained in the nanodroplets and ultrasound stimulation was required to trigger the release of the encapsulated drug and induce therapeutic effect [25]. In the second generation of nanoemulsions, PEG-PDLA copolymer with the elastic PDLA block was used as a nanodroplet stabilizer [6,26,34]. Ultrasound imaging showed that these nanodroplets disappeared from the site of injection within two days, presumable due to a fast PEG-PDLA biodegradation.…”

Section: Therapeutic Efficacy Of Micelles and Nanoemulsions: Effect Omentioning

confidence: 99%

Polymeric micelles and nanoemulsions as drug carriers: Therapeutic efficacy, toxicity, and drug resistance

Gupta

Shea

Scaife

et al. 2015

Journal of Controlled Release

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Phase-shift, stimuli-responsive Drug Carriers for Targeted Delivery

Cited by 37 publications

References 233 publications

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs

Experimental techniques for imaging and measuring transient vapor nanobubbles

Polymeric micelles and nanoemulsions as drug carriers: Therapeutic efficacy, toxicity, and drug resistance

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