PHBV nanocomposites based on organomodified montmorillonite and halloysite: The effect of clay type on the morphology and thermal and mechanical properties

Carli, Larissa N.; Crespo, Janaína da Silva; Mauler, Raquel Santos

doi:10.1016/j.compositesa.2011.07.007

Cited by 164 publications

(135 citation statements)

References 45 publications

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“…Among the most widely used biodegradable matrices in the production of nanobiocomposites, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has been widely cited in literature because it is a biodegradable polymer, of natural origin and, with similar physical properties to polyethylene and polypropylene [13,14]. PHBV is a copolymer of PHB obtained from the addition of 3-hydroxybutyrate and 3-hydroxyvalerate groups (HV), at different concentrations.…”

Section: Introductionmentioning

confidence: 99%

PHBV/cellulose nanofibrils composites obtained by solution casting and electrospinning process

2017

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In this work, nanobiocomposites of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) reinforced with cellulose nanofibrils (CNFs) were produced by electrospinning and solution casting process. CNFs were obtained by sulfuric acid hydrolysis from Imperata brasiliensis fibers. Nanocomposites loaded with 1 (wt. %) of CNFs were prepared using a mixture of solvents chloroform (CHCl 3 ): N, N-dimethylformamide (DMF), in the ratio of 78:22 with 30 h of solubilization. Films by solution casting were obtained in a petri dish, at 50 °C for 1 hour, using drying casting temperature of 153 °C. Mats by electrospinning were obtained with a needle 20x10, drum collector rotation 27 rpm, and working distance of 10 cm. Films and mats were characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC). It was possible to conclude that for nanobiocomposites obtained by solution casting, the addition of CNFs did not affect the transparency of the films, but provided a significant increase in the crystallization rate as observed by DSC analysis, while for electrospinning nanobiocomposites a considerable improvement in process increasing electrospinning time and quality of the mats manufactured, were observed.

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Section: Introductionmentioning

confidence: 99%

PHBV/cellulose nanofibrils composites obtained by solution casting and electrospinning process

2017

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“…From the differential scanning calorimetry data, the crystallinity of the samples was calculated according to the following formula: 21 Crystallinity…”

Section: Characterization Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Effect of biopolymers on the characteristics and cytocompatibility of biocomposite nanofibrous scaffolds

Kim

2013

Polym J

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Polymer blending is one of the most effective methods for providing new and desirable biocomposites for biomedical applications. To develop a new potential scaffold, biocomposite nanofibers composed of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), gelatin and laminarin were prepared using an electrospinning process. The resulting nanofibers exhibited a fully interconnected pore structure and their average diameter varied according to the mixing ratio of polymers. According to the X-ray diffraction results, the crystalline phase of PHBV was hardly affected by the addition of biopolymers. However, the crystallinity obtained from the differential scanning calorimetry data increased with a decrease of gelatin content from 30.9 to 53.3%. The water contact angles were markedly reduced by the addition of hydrophilic biopolymers from 941 to 451. The results from cytocompatibility tests showed that cell proliferation on the nanofibrous scaffolds increased with increasing gelatin content, whereas the improvement of proinflammatory cytokine expression was not proportional to the gelatin content. Therefore, PHBV/gelatin/laminarin (PHGL) biocomposite nanofibrous scaffolds appear to be promising biomaterials suitable for tissue engineering.

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“…Du et al (2006) functionalized the HNT surface with γ-aminopropyltriethoxysilane and then polypropylene chains were grafted onto the HNT surface with a resultant increase in mechanical properties compared with polypropylene alone or polypropylene/unmodified HNTs [31]. HNTs were successfully modified with different functionalized organosilanes, and interestingly, the analysis indicated that HNT dispersion in poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) led to various structures depending on the clay organomodifier [32]. The authors concluded that the mechanical properties of HNT/PHBV composites could be altered with the final composition dependent on the clay organomodifier [32].…”

Section: Introductionmentioning

confidence: 99%

“…HNTs were successfully modified with different functionalized organosilanes, and interestingly, the analysis indicated that HNT dispersion in poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) led to various structures depending on the clay organomodifier [32]. The authors concluded that the mechanical properties of HNT/PHBV composites could be altered with the final composition dependent on the clay organomodifier [32]. Furthermore, silane-functionalized HNTs have been developed for many applications in polymer matrices, such as epoxy resin [33], polypropylene [31], natural rubber [34], and ethylene-propylene-diene rubber [35].…”

Section: Introductionmentioning

confidence: 99%

Bi-Functionalized Clay Nanotubes for Anti-Cancer Therapy

et al. 2018

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Systemic toxicity is an undesired consequence of the majority of chemotherapeutic drugs. Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. Halloysite clay nanotubes (HNTs) have shown potential as a drug delivery vehicle, and its surface can be modified and tailored as a targeted drug delivery system. In this short report, we modified the HNT surface by covalently bonding folic acid (FA) and fluorescein isothiocyanate (FITC). The modification of HNTs with folic acid imparts the potential to target tumor cells selectively. The addition of FITC offers a method for quantifying the effectiveness of the FA tagged HNTs ability to target tumor cells. We documented cell uptake of our bi-functionalized HNT (bHNT) through phase contrast and epi-fluorescent microscopy. bHNTs showed no signs of cytotoxicity up to a concentration of 150 µg/mL. The increase in cell death with increased bHNT concentration may be due to induced cytotoxicity resulting from intracellular bHNT accumulation that disrupts cellular function leading to cell death. With HNTs recognized as having the ability to serve as both a nanocontainer and nanocarrier, we envision our construct as a potential modular platform for potential use in cancer therapeutics. The HNT interior can be loaded with a variety of anti-cancer drugs (or other chemotherapeutics) and serve as a "death cargo" designed to kill cancer cells while providing feedback imaging data on drug efficacy. The surface of the HNT can be modified with gold or silver nanoparticles and used in photothermal therapy by converting light to heat inside tumors. Our HNT-based drug delivery system has the potential to provide localized and targeted therapies that limit or reduce side effects, reduce patient costs and length of hospital stays, and improve quality of life. However, further research is needed to validate the potential of this new chemotherapeutic drug delivery system.

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PHBV nanocomposites based on organomodified montmorillonite and halloysite: The effect of clay type on the morphology and thermal and mechanical properties

Cited by 164 publications

References 45 publications

PHBV/cellulose nanofibrils composites obtained by solution casting and electrospinning process

PHBV/cellulose nanofibrils composites obtained by solution casting and electrospinning process

Effect of biopolymers on the characteristics and cytocompatibility of biocomposite nanofibrous scaffolds

Bi-Functionalized Clay Nanotubes for Anti-Cancer Therapy

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