Phenanthrylalkanoic Acids, IV¹⁾: Syntheses and Antiinflammatory Activity of 2‐, 3‐, and 9‐Phenanthryl‐ and 9‐Chloro‐3‐phenanthryl Derivatives of Propanoic Acid

Abstract

The phenanthrylethanols 2a-d were obtained by reduction of the acetyl derivatives 1a-d and converted, through the phenanthrylethyl halides 3a-d and 4b, into the nitriles 5a-d, whose acid hydrolysis afforded the acids of the title, 6a-d. The antiinflammatory activity of these acids was measured on the carrageenin-induced edema and found as 1/3 (6a), 1/43 (6b), 1/5 (6c), and 1/7 (6d) of that of fenbufen.

Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-d-aspartate Receptor Allosteric Modulators

“…Hydrolysis of the nitrile under acidic conditions yielded the 3-acetic acid derivative 43 (Scheme 7). 9 …”