Phencyclidine Induced Psychosis. The Need to Avoid Unnecessary Sensory Influx

Phencyclidine: An Overview

“…The autho rs pointed out, however, th at t h e re is a qualitative differ enc e between PCP a n d amph etamin e-induced ipsil ateral turn ing, a d iffe ren ce whi ch w a s expl ained by the mo re potent antich oline rgic eff ec t s of PCP (Finnegan , Kanner & Meltzer 1976). from an imbal ance between the cholinergic and dopaminergic systems in brain centers involved with the control o f em o t io n a l expression (Stein 1973). The unique psy chopharmacological properties of PCP tend to support such a m odel a n d suppl y at least a working model as to the biochemical basis of drug-induced psychosis.…”