Phenethylamine@Pillar[5]arene Biointerface for Highly Enantioselective Adsorption of Protein

Abstract

In the life system, the biointerface plays an important role in cell adsorption, platelet adsorption and activation. Therefore, the study of protein adsorption on the biointerface is of great significance for understanding life phenomena and treatment in vitro. In this paper, a chiral biointerface was constructed by the virtue of host‐guest interaction between a water‐soluble pillar[5]arene (WP5) and phenethylamine (PEA) over a gold surface for adsorption of lysozyme proteins. From the experimental results it was identified that the host‐guest biointerface has a high adsorption capacity and strong chiral selectivity. Furthermotre, it was identified that the host‐guest interaction plays the decisive role in the enhancement of chirality of the interface, which was much beneficial for increasing protein adsorption and amplifying the capacity of chiral discrimination. Therefore, this work provides a new idea for the construction of biointerface materials with high protein adsorption capacity and high chiral selectivity through supramolecular interaction, which will have potential applications in the fields of biosensors, biocatalysts, biomaterials.

Chiral pillar[5]arene-functionalized silica microspheres: synthesis, characterization and enantiomer separation

“…3,4 Chiral pillar[ n ]arenes can be easily obtained by using bulky groups to inhibit planar conformation inversion or introduce chiral groups on the edge of the benzene ring. 5–8 Subsequently, various chiral pillar[ n ]arene materials have been successfully prepared and applied in the chiral field, such as chiral self-locking molecules/rotaxane, 9–11 chiral biointerface materials, 12–14 chiral framework active domain materials, 15 chiral nanomaterials, 16 and chiral polymers. 17,18 Similarly, pillar[ n ]arene-based chiral materials such as highly sensitive chiral sensors and chiral nanofilms have yielded fascinating results due to their symmetric structure, planar chirality, chiral recognition or host–guest interaction.…”