Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

“…Beyond the compound-specific knowledge, these data are useful to further explore the impact of other nonmaturational factors e.g. drug-drug interactions (Allegaert et al, 2019). Based on in vivo observations, coadministration of phenobarbital, a CYP3A inducer, will for example increase midazolam CL in neonates treated with TH with a factor 2.3 (95% CI 1.9-2.9) (Favie et al, 2019).…”