1960
DOI: 10.1002/jcp.1030560411
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Phenogenetic aspects of some hair and pigment mutants

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Cited by 8 publications
(3 citation statements)
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“…On the other hand, it is also possible that at least some melanocytes revert to a dormant form which is indistinguishable from the epithelial cells of the follicle and are reactivated, perhaps producing mitotic descendents, when the next hair cycle is initiated (Chase, 1958;Quevedo and Chase, 1958). Although according to Chase (1958) the bulk of evidence supports the contention that there are stem cells at definite sites of the hair follicle which give rise to the mature and expendable melanocytes (see also discussion following Chase and Mann, 1960), and the situation in Bit follicles is consistent with this, there is also evidence (see Chapter 11, note 17) which indicates strongly that melanocytes (or their mitotic decendents) can, in fact, pigment more than one hair. Perhaps both possibilities occur, i.e., while some melanocytes may be able to pigment more than one hair, a stem cell source of new cells may also operate as an insurance mechanism.…”
Section: G Light (Bit)mentioning
confidence: 90%
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“…On the other hand, it is also possible that at least some melanocytes revert to a dormant form which is indistinguishable from the epithelial cells of the follicle and are reactivated, perhaps producing mitotic descendents, when the next hair cycle is initiated (Chase, 1958;Quevedo and Chase, 1958). Although according to Chase (1958) the bulk of evidence supports the contention that there are stem cells at definite sites of the hair follicle which give rise to the mature and expendable melanocytes (see also discussion following Chase and Mann, 1960), and the situation in Bit follicles is consistent with this, there is also evidence (see Chapter 11, note 17) which indicates strongly that melanocytes (or their mitotic decendents) can, in fact, pigment more than one hair. Perhaps both possibilities occur, i.e., while some melanocytes may be able to pigment more than one hair, a stem cell source of new cells may also operate as an insurance mechanism.…”
Section: G Light (Bit)mentioning
confidence: 90%
“…However, it also occurred at Brown University in 1955 as a spontaneous mutation in Chase's YZ57/Ch strain (Chase, 1959), a mutation that was known as "slate" (sit) until its allelism with bg was demonstrated (Lyon and Meredith, 1965b;see Chase, 1965). This mutation is currently referred to as bg"lt. Two mutations to beige have occurred also at the Jackson Laboratory, one in a yellow stock and the other in strain C57BL/6J (Lane, 1962) (Plate 3-A).…”
Section: A Originmentioning
confidence: 95%
“…The phenogenetics of hair and skin mutants is particularly amenable for analysis because many developmental and physiological processes, as well as associated pleiotropic effects, can be observed in late-foetal, post-natal, or even in adult animals. As developmental and physiological phenomena become better known through observations of variations attributable to mutant genes and teratogens, the biochemical steps underlying these phenomena will become more accessible for study (Chase & Mann, 1960).…”
Section: Introductionmentioning
confidence: 99%