Phenol peels as a novel therapeutic approach for actinic keratosis and Bowen disease: Prospective pilot trial with assessment of clinical, histologic, and immunohistochemical correlations

Two patterns of solar lentigines: A histopathological analysis of 40 Japanese women

“…After more washes in PBS, the sections were incubated in AEC (Nichirei Bioscience, Tokyo, Japan) for 10 min. The sections were counterstained with a hematoxylin modified solution, and mounted in an aqueous mounting medium 2 …”

“…recorded the pattern of the epidermis as “flattened epidermis” (FE) or “budding of rete ridges” (BUD). The extent of the solar elastosis, dermal melanophages and dermal inflammatory cells were evaluated in each group and scored as: 0, none; 1, minimal; 2, mild; 3, moderate; or 4, severe 2 . The data were evaluated with an unpaired Student’s t ‐test.…”

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

“…56 Phenol peels were applied to 14 patients with SCC in situ, with a complete response after one to eight treatment sessions in 71% (10/14), all remaining clear over a 1-year follow-up period. 110 Hypopigmentation was observed in certain cases and was more common with increased sessions. Topical tazarotene 0Á1% gel, an acetylenic retinoid, was applied daily for up to 6 months to SCC in situ in 15 patients, with histologically confirmed clearance in seven patients after 3-5 months of treatment.…”

Preventive effect of chemical peeling on ultraviolet induced skin tumor formation

“…Extensive clinical trial of chemical peeling on precancerous actinic keratosis was done with histologic evaluation and superficial skin tumors could be recognized as good candidates for the therapy [9,10]. Using hairless mice, carcinogenic potential of chemical peeling after repetitive irradiation of UVB was studied with salicylic acid in polyethylene glycol (PEG) and 35% trichloroacetic acid (TCA).…”