Phenolic acid composition and anticancer activity against human cancer cell lines of the commercially available fermentation products of Houttuynia cordata

Senawong, Thanaset; Khaopha, Somprasong; Misuna, Suwatchai; Komaikul, Jeeranan; Senawong, Gulsiri; Wongphakham, Paweena; Yunchalard, Sirinda

doi:10.2306/scienceasia1513-1874.2014.40.420

Cited by 39 publications

(32 citation statements)

References 25 publications

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“…Chemotherapy is an effective way to treat many types of cancers, but the cost of treatment is a major public health concern in developing countries. Anti-cancer drugs used to treat patients often are expensive, and most of them cause negative side effects, especially to normal cells that have a high proliferation rate, affecting most cancer patients [3].…”

Section: Colon Cancermentioning

confidence: 99%

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Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

LS¹,

NJA²

2016

J Nutr Food Sci

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Consumption of fruits and vegetables is associated with lower risk of several cancers, particularly colorectal cancer, which is mainly associated to their phytochemical content. A diverse range of phytochemicals, especially phenolic compounds, has been reported to possess important biological properties such as anticancer, antiviral, antioxidant and anti-inflammatory activities. Several factors contribute to the development of colorectal cancer. The scientific evidences support the genetic predisposition, diet, and lifestyle as some of the major contributing factors for colorectal cancer development. In this sense, this review aims to summarize the anticancer activities and the proposed mechanisms of action of phenolic acids with an emphasis in colon cancer through in vitro evidences. The evidences supports the theory of anticancer properties of phenolic acids, although the mechanisms are still not fully understood, but may include scavenging free radicals, induction of enzymes involved in the metabolism of xenobiotics, regulation of gene expression, modulation of cellular signaling pathways including those involved in DNA damage repair, cell proliferation, apoptosis and invasion.

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Section: Colon Cancermentioning

confidence: 99%

“…The potential biological effects of various constituents of fruits and vegetables suggested a plausible mechanism for protective effects, such as by reducing oxidative damage of DNA or increasing the activity of enzymes able to detoxify carcinogens [2,3].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

LS¹,

NJA²

2016

J Nutr Food Sci

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“…MTT and Annexin V. staining assays were used to investigate anti-proliferative and apoptosis induction activities. The results showed that commercially available fermentation products of H. cordatacontain several anticancer phenolic acids that may be beneficial in the treatment of human cancer [34].…”

Section: Senawong Et Al (2014)mentioning

confidence: 99%

Medicinal plants: used in Anti-cancer treatment

Tyagi¹,

Sharma²,

Shrivastava³

et al. 2017

IJRDPL

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ABSTRACT:Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life -threatening disease. The plant kingdom produces naturally occurring secondary metabolites which are being investigated for the anticancer activities for the development of new clinical drugs. For many years herbal medicines have been used and are still used in developing countries as the primary source of medical treatment. Plants have been used in the medicine for their natural antiseptic properties. Thus, research has developed into the investigating the potential properties and uses of terrestrial plants extracts for the preparation of potential nanomaterial drugs for diseases including cancer. Many plant species are already being used to treat or prevent development of cancer. This review discusses the demand for naturally derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments.

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“…The fermented H. cordata protects the cells (RAW264.7 and RBL-2H3) from LPS-induced toxicity and suppresses the growth of HepG2 cells (human liver cancer cells) [20]. Senawong et al [34] studied the anticancer activity of commercially available fermented H. cordata products (CFH) of Thailand. About seven phenolic compounds were detected in CFH, and some of the CFH exhibited dose-dependentantiproliferative activity against HCT116, HT29, and HeLa cells.…”

Section: Chaiyasut Et Almentioning

confidence: 99%

Assessment of Subchronic Toxicity of Fermented Houttuynia Cordata Thunb. Using Rodent Model System

Chaiyasut

Sivamaruthi

Duangjitcharoen

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study was intended to evaluate the subchronic toxicity of Lactobacillus-mediated fermented Houttuynia cordata juice (FHJ) using rodent model system. Methods:FHJ was prepared and the microbial load, lactic acid content, and pH was estimated. Rats were fed with different doses of FHJ for 60 days. The body mass changes were measured during FHJ supplementation. After the treatment period, blood and organs of the experimental rats were collected. The samples were subjected to hematological and biochemical analysis by following standard hospital protocols. Results:The pH of FHJ after 30 days of fermentation was 3.63. The lactic acid content of FHJ was gradually increased and reached 19.70 mg per mL after 30 days of the fermentation process. Lactobacillus load was high in FHJ after 30 days and no Bacillus spp. and yeast were detected in FHJ at any point of fermentation. There were no significant changes in body weight of male and female experimental rats supplemented with FHJ, irrespective of dose. There were no significant treatment-related pathological changes found in any organ of the experimental rats at all tested dose levels when compared with organs in control animals. There were no significant changes observed in red blood cells (RBCs), white blood cells (WBCs), hemoglobin, hematocrits, lymphocyte, and platelets level of male rats of all groups. Whereas, significant (p<0.01) changes were observed in the RBC (1.02±0.26 106/mm 3 ) of female rats in effective dose (ED) group compared to control. Similarly, significant (p<0.01) changes were detected in the WBC level of female rats in high dose (−7.53±0.03 103/mm3), and post-ED group (−8.86±0.75 103/mm 3 ) compared to control. There were no alterations in tested biochemical parameters of experimental rats. Conclusion:The FHJ was rich in probiotic Lactobacillus. The supplementation of FHJ (9 mL/kg/day) for 60 days did not significantly affect the body mass, internal organs, hematological, and biochemical parameters of rats. The results suggested that FHJ is qualified for the human consumption.

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Phenolic acid composition and anticancer activity against human cancer cell lines of the commercially available fermentation products of Houttuynia cordata

Cited by 39 publications

References 25 publications

Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

Medicinal plants: used in Anti-cancer treatment

Assessment of Subchronic Toxicity of Fermented Houttuynia Cordata Thunb. Using Rodent Model System

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