Phenolic acid profiles and antioxidant potential of Pelargonium sidoides callus cultures

Kumar, Vijay; Moyo, Mack; Grúz, Jiří; Šubrtová, Michaela; Staden, J. Van

doi:10.1016/j.indcrop.2015.09.009

Cited by 24 publications

(3 citation statements)

References 35 publications

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“…In addition, phenolic acids can directly absorb and neutralize free radicals, and inhibit enzymes associated with ROS generation pathways (such as xanthine oxidase, NADPH oxidase, and myeloperoxidase) [ 29 , 30 ]. Phenolic acids also enhance the activities of human antioxidant enzymes, including superoxide dismutase and catalase [ 29 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

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Preparation, Characterization, and Biological Activities of Topical Anti-Aging Ingredients in a Citrus junos Callus Extract

et al. 2017

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In this study, we prepared and characterized a callus extract from Citrus junos and assessed its utility as a source of topical anti-aging ingredients. Callus extract was produced by aqueous extraction from Citrus junos grown on Murashige and Skoog medium with picloram as a growth regulator. After measuring the total phenolic and flavonoid contents, the major phenolic compound in calli was identified as p-hydroxycinnamoylmalic acid (1) by spectroscopic analysis. The total phenol content in the extract was determined to be 24.50 ± 0.43 mg/g of gallic acid equivalents; however, the total flavonoid content of the extract was not determined. The biological activities of the callus extract, in terms of skin anti-aging, were assessed by measuring the anti-tyrosinase activity in, and melanogenesis by, melanoma cells; and proliferation of, and procollagen synthesis by, human fibroblasts. The callus extract was incorporated into nanoliposomes (NLs) to improve its percutaneous absorption. Addition of the callus extract resulted in a 1.85-fold decrease in the melanin content of melanocytes compared with that with arbutin. The extract (500 μg/mL) significantly promoted the proliferation of, and procollagen synthesis by, fibroblasts (by 154% and 176%, respectively). In addition, the flux through the human epidermis of Citrus junos callus extract incorporated into NLs was 17.67-fold higher than that of the callus extract alone. These findings suggest that Citrus junos callus extract-loaded NLs have promise as an anti-aging cosmetic, as well as having a skin-lightening effect.

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Section: Resultsmentioning

confidence: 99%

“…As a linear correlation between phenolic concentration and radical-scavenging activity has been reported in the extracts of many plants, vegetables, and fruits, we expected that the Citrus junos callus extract would exhibit strong antioxidant activity [ 30 , 31 ]. Figure 2 shows the DPPH radical-scavenging activity of the extract.…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Biological Activities of Topical Anti-Aging Ingredients in a Citrus junos Callus Extract

et al. 2017

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“…Pelargonium sidoides, a medical plant indigenous to South Africa, is traditionally used for the treatment of various ailments and has been developed into an internationally successful herbal medicine to treat bronchitis and other respiratory-related ailments (Brendler and van Wyk 2008;Kumar et al 2015). The original Pelargonium sidoides root extract, today known as EPs ® 7630, consists of many important secondary metabolites, including coumarins, phenolic acids, flavonoids, tannins, and their derivatives (Kolodziej 2020;Kolodziej 2007;Schotz and Noldner 2007;Schnitzler et al 2008;Schoetz et al 2008;Hauer et al 2010;Maree and Viljoen 2012).…”

Section: Introductionmentioning

confidence: 99%

Development and application of a chemical profiling method for the assessment of the quality and consistency of the Pelargonium sidoides extract

Yu¹,

Kim²,

Yoon

et al. 2021

J Anal Sci Technol

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The evaluation of chemical similarity is very significant for the evaluation and standardization of the quality of herbal medicines as the biological activity of herbal medicines depends on the composition and proportion of many individual components. Many health organizations have recommended chemical profiling for the quality and consistency evaluation of herbal medicines. In this study, chemical profiling was performed to evaluate the similarity between batches of Pelargonium sidoides maltodextrin mixture (PMM) from EPs® 7630, a Pelargonium sidoides extract preparation. For chemical profile analysis, 7 common peaks were selected from 27 different PMM batches and specificity, linearity, accuracy, and precision tests were performed to develop the analytical method. The Pearson correlation coefficients of the similarity for all 27 batches manufactured over the years were higher than 0.90, indicating that quality consistency is well ensured over the years. This profiling method confirms the chemical profile of various commercial products using not only PMM but also Pelargonium sidoides extract and shows that it can be applied to standardization of quality.

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The Applications of TDZ in Medicinal Plant Tissue Culture

Deepa

Anju

Thomas

2018

Thidiazuron: From Urea Derivative to Plant Growth Regulator

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Phenolic acid profiles and antioxidant potential of Pelargonium sidoides callus cultures

Cited by 24 publications

References 35 publications

Preparation, Characterization, and Biological Activities of Topical Anti-Aging Ingredients in a Citrus junos Callus Extract

Preparation, Characterization, and Biological Activities of Topical Anti-Aging Ingredients in a Citrus junos Callus Extract

Development and application of a chemical profiling method for the assessment of the quality and consistency of the Pelargonium sidoides extract

The Applications of TDZ in Medicinal Plant Tissue Culture

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