Phenolic compounds from roots of Urtica dioica

Kraus, Rupert; Spiteller, Gerhard

doi:10.1016/0031-9422(90)80140-c

Cited by 36 publications

(15 citation statements)

References 6 publications

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“…The phenolic constituents of ERU have already been the subject of investigations (15,16), but still there is little knowledge about the amount of the lignans. Determination of the concentration of the active (-)-secoisolariciresinol (1) was achieved by addition of (±)-d4-secoisolariciresinol (4) as an internal standard to an aqueous ERU solution, used for pharmaceutical applications.…”

Section: Resultsmentioning

confidence: 99%

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Lignans from the Roots ofUrtica dioicaand their Metabolites Bind to Human Sex Hormone Binding Globulin (SHBG)

Schöttner

Ganßer²,

Spiteller³

1997

Planta Med

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Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).

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Section: Resultsmentioning

confidence: 99%

“…mt.) = 358 [Mi] (84), 327 (13), 180(16), 163 (39), 153(12), 152 (42), 151 (100), 150 (33), 137(64), 131 (34). 1H-NMR, 13CNMR and [a]3 are in agreement to(12, 13).…”

mentioning

confidence: 99%

Lignans from the Roots ofUrtica dioicaand their Metabolites Bind to Human Sex Hormone Binding Globulin (SHBG)

Schöttner

Ganßer²,

Spiteller³

1997

Planta Med

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“…Extracts of U. dioica roots have been used in the treatment of BPH (4). Although the specific principle that subserves this use has not been identified, the roots _____________________________________ have a number of pharmacological activities (1)(2)(3). If SHBG is involved in the pathophysiology of BPH, then it is possible that such extracts work by a mechanism involving the SHBG receptor.…”

Section: Germanymentioning

confidence: 99%

“…The roots of the stinging nettle (Urtica dioica L.) contain a complex mixture of water-and alcohol-soluble compounds including lectins, phenols, sterois, and lignans (1)(2)(3). In addition, extracts of the roots of U. die/ca have been shown to exert a number of pharmacologic activities (2,3).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Extracts of the Roots of the Stinging Nettle(Urtica dioica)on the Interaction of SHBG with its Receptor on Human Prostatic Membranes

Hryb

Khan²,

Romas³

et al. 1995

Planta Med

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Extracts from the roots of the stinging nettle (Urtica dioica) are used in the treatment of benign prostatic hyperplasia. The mechanisms underlying this treatment have not been elucidated. We set out to determine whether specific extracts from U. dioica had the ability to modulate the binding of sex hormone-binding globulin to its receptor on human prostatic membranes. Four substances contained in U. dioica were examined: an aqueous extract; an alcoholic extract; U. dioica agglutinin, and stigmasta-4-en-3-one. Of these, only the aqueous extract was active. It inhibited the binding of 125I-SHBG to its receptor. The inhibition was dose related, starting at about 0.6 mg/ml and completely inhibited binding at 10 mg/ml.

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“…Both aerial parts and belowground parts of stinging nettles are used in the herbal dietary supplement industry. Throughout the literature, there are conflicting and confusing terms describing the below-ground parts of stinging nettles, with most authors reporting use of roots in research and clinical trials (e.g., Sokeland, 2000;Testai et al, 2002;Kraus and Spiteller, 1990;Belaiche and Lievoux, 1991;Schottner et al, 1997). Other researchers report rhizomes (e.g., Weglarz and Roslon, 2000;World Health Organization, 1999).…”

Section: Multi-product Crop (Herb Rhizome and Root)mentioning

confidence: 99%

Aeroponic and Hydroponic Systems for Medicinal Herb, Rhizome, and Root Crops

Hayden¹

2006

HortSci

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Hydroponic and aeroponic production of medicinal crops in controlled environments provides opportunities for improving quality, purity, consistency, bioactivity, and biomass production on a commercial scale. Ideally, the goal is to optimize the environment and systems to maximize all five characteristics. Examples of crop production systems using perlite hydroponics, nutrient film technique (NFT), ebb and flow, and aeroponics were studied for various root, rhizome, and herb leaf crops. Biomass data comparing aeroponic vs. soilless culture or field grown production of burdock root (Arctium lappa), stinging nettles herb and rhizome (Urtica dioica), and yerba mansa root and rhizome (Anemopsis californica) are presented, as well as smaller scale projects observing ginger rhizome (Zingiber officinale) and skullcap herb (Scutellaria lateriflora). Phytochemical concentration of marker compounds for burdock and yerba mansa in different growing systems are presented.

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Phenolic compounds from roots of Urtica dioica

Cited by 36 publications

References 6 publications

Lignans from the Roots ofUrtica dioicaand their Metabolites Bind to Human Sex Hormone Binding Globulin (SHBG)

Lignans from the Roots ofUrtica dioicaand their Metabolites Bind to Human Sex Hormone Binding Globulin (SHBG)

The Effect of Extracts of the Roots of the Stinging Nettle(Urtica dioica)on the Interaction of SHBG with its Receptor on Human Prostatic Membranes

Aeroponic and Hydroponic Systems for Medicinal Herb, Rhizome, and Root Crops

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