Phenolic Compounds Isolated from Caesalpinia coriaria Induce S and G2/M Phase Cell Cycle Arrest Differentially and Trigger Cell Death by Interfering with Microtubule Dynamics in Cancer Cell Lines

Sánchez‐Carranza, Jessica Nayelli; Álvarez, Laura; Marquina‐Bahena, Silvia; Salas‐Vidal, Enrique; Cuevas, Verónica; Jiménez, Elizabeth W; G, Rafael A Veloz; Carraz, M; González‐Maya, Leticia

doi:10.3390/molecules22040666

Cited by 46 publications

(36 citation statements)

References 31 publications

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“…In addition, pyrogallol inhibits human lung adenocarcinoma Calu-6 cell via caspase-dependent apoptosis and cell cycle arrest [49,50]. Moreover, ethyl gallate, which is a phenolic compound, has been reported to exhibit anticancer activity against many cell lines such as human prostate cancer PC3, cervical cancer HeLa and CaSki, human hepatocellular carcinoma Hep3B and HepG2 cells [51]. In previous studies ethyl gallate induces HL-60 apoptosis via the mitochondria-mediated pathway.…”

Section: Discussionmentioning

confidence: 96%

Potential of Thai Herbal Extracts on Lung Cancer Treatment by Inducing Apoptosis and Synergizing Chemotherapy

et al. 2020

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The incidence of lung cancer has increased while the mortality rate has continued to remain high. Effective treatment of this disease is the key to survival. Therefore, this study is a necessity in continuing research into new effective treatments. In this study we determined the effects of three different Thai herbs on lung cancer. Bridelia ovata, Croton oblongifolius, and Erythrophleum succirubrum were extracted by ethyl acetate and 50% ethanol. The cytotoxicity was tested with A549 lung cancer cell line. We found four effective extracts that exhibited toxic effects on A549 cells. These extracts included ethyl acetate extracts of B. ovata (BEA), C. oblongifolius (CEA), and E. succirubrum (EEA), and an ethanolic extract of E. succirubrum (EE). Moreover, these effective extracts were tested in combination with chemotherapeutic drugs. An effective synergism of these treatments was found specifically through a combination of BEA with methotrexate, EE with methotrexate, and EE with etoposide. Apoptotic cell death was induced in A549 cells by these effective extracts via the mitochondria-mediated pathway. Additionally, we established primary lung cancer and normal epithelial cells from lung tissue of lung cancer patients. The cytotoxicity results showed that EE had significant potential to be used for lung cancer treatment. In conclusion, the four effective extracts possessed anticancer effects on lung cancer. The most effective extract was found to be E. succirubrum (EE).

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Section: Discussionmentioning

confidence: 96%

Potential of Thai Herbal Extracts on Lung Cancer Treatment by Inducing Apoptosis and Synergizing Chemotherapy

et al. 2020

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“…By comparison of experiment and reported spectroscopic data ([α] D , UV, IR, NMR, and MS), known compounds were identified as one apocarotenoid: deglucosyl lauroside B (5) [36], seven benzenoids: gallic acid (6) [37], methyl gallate (7)…”

Section: Identification Of Known Compounds 5-44mentioning

confidence: 99%

Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana

Cheng

Yen

et al. 2020

Molecules

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Hepatocellular carcinoma (HCC) is considered to be a silent killer, and was the fourth leading global cause of cancer deaths in 2018. For now, sorafenib is the only approved drug for advanced HCC treatment. The introduction of additional chemopreventive agents and/or adjuvant therapies may be helpful for the treatment of HCC. After screening 3000 methanolic extracts from the Formosan plant extract bank, Excoecaria formosana showed glycine N-methyltransferase (GNMT)-promoter-enhancing and nuclear factor erythroid 2-related factor 2 (NRF2)-suppressing activities. Further, the investigation of the whole plant of E. formosana led to the isolation of a new steroid, 7α-hydroperoxysitosterol-3-O-β-d-(6-O-palmitoyl)glucopyranoside (1); two new coumarinolignans, excoecoumarin A (2) and excoecoumarin B (3); a new diterpene, excoeterpenol A (4); and 40 known compounds (5–44). Among them, Compounds 38 and 40–44 at a 100 μM concentration showed a 2.97 ± 0.27-, 3.17 ± 1.03-, 2.73 ± 0.23-, 2.63 ± 0.14-, 6.57 ± 0.13-, and 2.62 ± 0.05-fold increase in GNMT promoter activity, respectively. In addition, Compounds 40 and 43 could reduce NRF2 activity, a transcription factor associated with drug resistance, in Huh7 cells with relative activity of 33.1 ± 0.2% and 45.2 ± 2.5%. These results provided the basis for the utilization of Taiwan agarwood for the development of anti-HCC agents.

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“…Other study showed G2/M phase cell arrest with sulforaphane compound found in R. sativus methanolic extract (Pledgie-Tracy et al, 2007). The treated HepG2 cells with 1/10 of IC50 of A. santolina induce sub G0 phase apoptosis (Sánchez-Carranza et al, 2017).…”

Section: Disscussionmentioning

confidence: 88%

In vitro Apoptotic effects of the medicinal plants Achillea santolina and Raphanus sativus extracts on different cancer cell lines

Mohasseb

Salem

Gaafar

et al. 2019

Journal of Cancer and Biomedical Research

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The extracts of the medicinal plants Achillea santolina and Raphanu sativus have been reported to show anti-cancer effects in vitro. However the cellular and molecular mechanism of these effects are not clear yet. To compare the apoptotic effects of these plant extracts on different cance cell lines in vitro. The phenolic, flavonoids and antioxidant activity were determined in the crude extracts. Then, Caco2 (colon adenocarcinoma) HepG2 (hepatic carcinoma), MCF7 (breast cancer) and the normal WISH (amniotic cell line) were treated in vitro with different concentrations o crude extracts for 72 hours. The half maximal inhibitory concentration (IC50 were detected by MTT assay, while cell cycle and apoptosis were assessed by flow cytometry. The methanolic extract of R. sativus seeds (cultivar Balady) showed higher phenolic content (791.98 mg/d.wt) and highe antioxidant activity (93%) than those of the ethanolic extract of A. santolina (340.23 mg/d.wt) and (72.72%), respectively. R. sativus methanolic extrac showed lower flavonoids contents (1.025 mg/g d.wt) than A. santolina ethanolic extract (24.66 mg/g d.wt). Treatment of Caco2, HepG2, MCF7 and WISH cell lines with A. santolina extract showed IC50 of 17.67 µg/ml, 15.12 µg/ml, 42.19 µg/ml and 50.99 µg/ml, respectively. While treatment of the same cell line with R. sativus showed IC50 of 40.77 µg/ml, 27.42 µg/ml 54.16 µg/ml and 86.37 µg/ml respectively. A. santolina and R. sativu extracts induced similar cell cycle arrest in Caco2 at G1 phase by 42.4% This study indicates that A. santolina has a potent anticancer activity against the selected cancer cell lines. ABSTRACT ARTICLE INFO-2-

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Phenolic Compounds Isolated from Caesalpinia coriaria Induce S and G2/M Phase Cell Cycle Arrest Differentially and Trigger Cell Death by Interfering with Microtubule Dynamics in Cancer Cell Lines

Cited by 46 publications

References 31 publications

Potential of Thai Herbal Extracts on Lung Cancer Treatment by Inducing Apoptosis and Synergizing Chemotherapy

Potential of Thai Herbal Extracts on Lung Cancer Treatment by Inducing Apoptosis and Synergizing Chemotherapy

Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana

In vitro Apoptotic effects of the medicinal plants Achillea santolina and Raphanus sativus extracts on different cancer cell lines

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