Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum

Xiong, Juan; Liu, Xinhua; Bui, Van-Binh; Zhang, Hong; Wang, Lijun; Zhao, Yun; Yang, Guo‐Xun; Hu, Jin‐Feng

doi:10.1016/j.fitote.2014.02.002

Cited by 27 publications

(22 citation statements)

References 24 publications

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“…Two new [named salicifoxazines A (1) and B (2)] and six known dimeric tryptamine-derived alkaloids (3)(4)(5)(6)(7)(8) were isolated from the leaves of Chimonanthus salicifolius. The new structures were established on the basis of extensive spectroscopic methods and chemical transformations.…”

Section: Introductionmentioning

confidence: 99%

“…1). By comparing their observed and reported spectroscopic data and physicochemical properties, the known compounds were determined as (À)-chimonanthine 10 (3, 40.0 mg), meso-chimonanthine 11 (4, 15.8 mg), (À)-folicanthine 12,8d (5, 4.2 mg), (+)-calycanthine 11,8b (6, 35.0 mg), (À)-iso-calycanthine 11,8c (7, 1.3 mg), and (3aR,3 0 aR,8-8a,8 0 -8 0 a)-tetradehydroisocalycanthine 13 4. In addition, the UV spectrum of 1 showed absorption bands at 241 and 298 nm indicative of a typical PhNCN chromophore.…”

Section: Introductionmentioning

confidence: 99%

“…Biosynthetic pathways for the known tryptamine-derived structures (3)(4)(5)(6)(7)(8) product I, which might furnish the 1,2-oxazine-containing structure III (1 and 2) via either path A or path B. In path A, monooxidation of the precursor I could give a hydroxylamine structure II, which would then form the oxazinoindoline III by cyclization.…”

Section: Introductionmentioning

confidence: 99%

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Salicifoxazines A and B, new cytotoxic tetrahydro-1,2-oxazine-containing tryptamine-derived alkaloids from the leaves of Chimonanthus salicifolius

Yang

Xiong

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salicifoxazines A and B, new cytotoxic tetrahydro-1,2-oxazine-containing tryptamine-derived alkaloids from the leaves of Chimonanthus salicifolius

Yang

Xiong

et al. 2015

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“…It is consumed in northeast Thailand as side dishes to relieve fever and stomach ache. In south and southwest China, it is used as ordinary tea (Xiong et al, 2014). The ethanolic extract of Teawdang leave contained toxyloxanthone B and vismione D which have anti-neuroinflammatory activity (Xiong et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…In south and southwest China, it is used as ordinary tea (Xiong et al, 2014). The ethanolic extract of Teawdang leave contained toxyloxanthone B and vismione D which have anti-neuroinflammatory activity (Xiong et al, 2014). Teaw contained chlorogenic acid (Maisuthisakul et al, 2006) which had high antioxidant activity and high cytotoxic effect to oral squamous cell carcinoma (HSC-2 cell line) (Jiang et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Cratoxylum Formosum Subsp. Pruniflorum Gogel Extracts in Oral Cancer Cell Lines

Promraksa

Daduang²,

Chaiyarit³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Oral cancer is a health problem in Thailand. Cratoxylum formosum subsp. pruniflorum Gogel (Teawdang), normally consumed in northeast Thailand, has proven cytotoxic to cervical cancer cell lines including HeLa, SiHa and C-33A. Recently, Asian oral cancer cell lines, ORL-48 and ORL-136, were established. Therefore, we aimed to study cytotoxicity of Teawdang in these. Total phenolic (TPC) and flavonoid content (TFC), and antioxidant activity of Teawdang were also determined. Materials and Methods: Teawdang was purchased from Khon Kaen market during June-October 2013. Hexane (CHE), ethyl acetate (CEE) and methanol (CME) extracts of its edible part were analyzed for TPC by the folin-ciocalteau method and for TFC by an aluminium colorimetric method. Antioxidant activity and cytotoxicity in normal Vero cells and oral cancer cells were investigated. Cell viability was assessed using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Results: CME and CEE had higher TPC and TFC and antioxidant activity than CHE. Both CME and CEE, at 200 µg dry wt/mL, were cytotoxic to the studied oral cancer cell lines. However, CME was cytotoxic to Vero cells whereas CEE was not. Compared to Vero cells, CEE significantly inhibited ORL-48 and ORL-136 growth (p=0.03 and p=0.02, respectively). Conclusions: CEE exhibited cytotoxic effects on the studied oral cancer cell lines but not normal Vero cells. The bioactive compounds in CEE should be further purified and elucidated for their mechanisms of action for development as anticancer agents.

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Chemical Constituents of the Rare Cliff Plant Oresitrophe rupifraga and Their Antineuroinflammatory Activity

Xiong

Liu

et al. 2016

Chemistry & Biodiversity

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Four new (1 - 4) and thirteen known (5 - 17) compounds were isolated from a rare cliff plant, Oresitrophe rupifraga. Based on spectroscopic evidence, the new structures were established to be [(2S,3R,4R)-4-(4-methoxybenzyl)-2-(4-methoxyphenyl)-tetrahydrofuran-3-yl]methanol (1), (3α)-23-(acetyloxy)-3-hydroxyolean-12-en-29-oic acid (2), 3α,23-(isopropylidenedioxy)olean-12-en-29-oic acid (3, artifact of isolation), and (3β,15β)-3-hydroxycholest-5-en-15-yl β-d-glucopyranoside (4), respectively. Among the isolates, compounds 1, 4, epieudesmin (7), and 1-O-(9Z,12Z,15Z-octadecatrienoyl)glycerol (17) were found to show significant antineuroinflammatory effects by inhibiting the NO production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC50 values of 7.21, 9.39, 4.96, and 8.51 μm, respectively.

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Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum

Cited by 27 publications

References 24 publications

Salicifoxazines A and B, new cytotoxic tetrahydro-1,2-oxazine-containing tryptamine-derived alkaloids from the leaves of Chimonanthus salicifolius

Salicifoxazines A and B, new cytotoxic tetrahydro-1,2-oxazine-containing tryptamine-derived alkaloids from the leaves of Chimonanthus salicifolius

Cytotoxicity of Cratoxylum Formosum Subsp. Pruniflorum Gogel Extracts in Oral Cancer Cell Lines

Chemical Constituents of the Rare Cliff Plant Oresitrophe rupifraga and Their Antineuroinflammatory Activity

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