Phenolic Constituents of Platanus Orientalis L. Leaves

Abstract

A new flavonoid glycoside, 5,7,4´-trihydroxy-3,6-dimethoxyflavone-3´-O-β-D-xylopyranoside (axillarin-3´-O-β-Dxylopyranoside), was isolated from the ethyl acetate fraction of the ethanolic extract of Platanus orientalis L. leaves, along with nine known flavonoid aglycones and glycosides, a phenolic acid and a phenolic acid derivative. Their structures were established on the basis of detailed spectral analysis. The total ethanolic, aqueous and ethyl acetate extracts of the leaves were tested for antihepatotoxic, antioxidant and cytotoxic activities. The extracts were found to be effective in protection against CCl 4 liver injury by significantly lowering alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. The extracts also significantly restored depleted levels of glutathione, indicating a strong antioxidant activity, while they showed variable cytotoxic activity.

In Vitro Antioxidant Potential of Leaves Extracts from Celtis australis .L

“…It is to note that standard BHT was more potent (96% at 30µg/ml). These results are corroborated by previous studies using various extracts of different parts of C. australis [16,22].…”

Two Novel Acylated Flavonol Glycosides from Platanus Orientalis L. Leaves

“…In a previous study [6] of the ethyl acetate fraction of P. orientalis leaves, the authors reported the isolation of a new flavonoid glycoside, 5,7,4´-trihydroxy-3,6dimethoxyflavone-3´-O-β-xylopyranoside (axillarin-3´-O-β-xylopyranoside), in addition to nine known flavonoid aglycones and glycosides, a phenolic acid and a phenolic acid derivative. The antioxidant, hepatoprotective and cytotoxic activities of the extracts were also studied.…”

Διερεύνηση Της Επίδρασης Φυσικών Προϊόντων, Προερχόμενων Από Φυτά Της Ελληνικής Χλωρίδας Στο Μεταβολισμό Των Οστών

“…Ένα ακόμη γένος που επιλέχθηκε λόγω των περιεχόμενων δευτερογενών μεταβολιτών του είναι το γένος Platanus. Τα είδη Platanus orientalis και Platanus acerifolia περιέχουν σημαντικές ποσότητες φλαβονοειδών, με κύριους εκπροσώπους τις φλαβονόλες[330,331,332] και μεταξύ αυτών κυρίως παράγωγα καιμφερόλης[333,334]. Η καιμφερόλη έχει χαρακτηριστεί για τις οστεοπροστατευτικές της ιδιότητες, όπως αναφέρθηκε και παραπάνω στο γένος Melilotus, τόσο in vitro σε καλλιέργειες οστεοβλαστών[279,335], όσο και σε in vivo μοντέλα οστεοπόρωσης[280,336].Η επιλογή ειδών του γένους Polygonum, βασίστηκε σε μελέτες συγγενών ειδών του γένους που έδειξαν οστεοπροστατευτικές ιδιότητες.…”