Phenolic Constituents with Inhibitory Activities on Acetylcholinesterase from the Rhizomes of Gastrodia elata

Ma, Qing‐Yun; Wan, Qin-Li; Huang, Sheng‐Zhuo; Dai, Hao‐Fu; Wu, Yingrui; Zhou, Jun; Luo, Huai‐Rong; Zhao, You‐Xing

doi:10.1007/s10600-015-1228-5

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Gastrodin A was found in addition to 1, demonstrating that the unusual saccharosyl linkage is not unprecedented (Fig. 5S, Supporting Information) [27]. Overall, the structural elucidation data gave no reason to doubt that Schumacher et al [1] actually isolated 1 from valerian root and elucidated the structure correctly.…”

Section: The Lignans Massoniresinol-4′-mentioning

confidence: 88%

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root

2020

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The lignan 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil had previously been discovered in a methanolic extract of valerian root (Valeriana officinalis agg.) and characterized as a potent partial agonist at the A1 adenosine receptors. Today, countless scientific sources, webpages, and press articles mention this compound and discuss it as an active constituent for the sedative effect of this herbal drug. As no second report confirmed the occurrence of this lignan in valerian root during the 20 years since its first description in 1998, we intended to re-prove its presence by means of LCMS using other genuine or added lignans as a quantitative benchmark. Whilst those lignans were clearly detectable in methanolic valerian extracts of all six investigated batches of valerian root, no positive proof of 4′-O-β- d-glucosyl-9-O-(6″-deoxysaccharosyl)olivil was achieved. Our result suggests that this compound does not occur regularly in valerian root in the amounts expected from the single report on the occurrence of this compound.

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Section: The Lignans Massoniresinol-4′-mentioning

confidence: 88%

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root

2020

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“…Gastrodiae rhizoma , the dried tuber of G. elata, is mainly used to treat affections of the central nervous system, such as headache, migraine, dizziness, and epilepsy [ 2 ]. Previous scientific works have provided in vitro and in vivo pharmacological evidence of neuroprotective activity [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ], antidepressant [ 12 , 13 ], antioxidant [ 14 , 15 , 16 , 17 , 18 , 19 ] and anti-inflammatory effects [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactivity Profiling and Quantification of Gastrodin in Gastrodia elata Cultivated in the Field versus Facility via Hyphenated High-Performance Thin-Layer Chromatography

Mügge

Sim

Honermeier

et al. 2023

IJMS

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Gastrodia elata (Orchidaceae) is native to mountainous areas of Asia and is a plant species used in traditional medicine for more than two thousand years. The species was reported to have many biological activities, such as neuroprotective, antioxidant, and anti-inflammatory activity. After many years of extensive exploitation from the wild, the plant was added to lists of endangered species. Since its desired cultivation is considered difficult, innovative cultivation methods that can reduce the costs of using new soil in each cycle and at the same time avoid contamination with pathogens and chemicals are urgently needed on large scale. In this work, five G. elata samples cultivated in a facility utilizing electron beam-treated soil were compared to two samples grown in the field concerning their chemical composition and bioactivity. Using hyphenated high-performance thin-layer chromatography (HPTLC) and multi-imaging (UV/Vis/FLD, also after derivatization), the chemical marker compound gastrodin was quantified in the seven G. elata rhizome/tuber samples, which showed differences in their contents between facility and field samples and between samples collected during different seasons. Parishin E was also found to be present. Combining HPTLC with on-surface (bio)assays, the antioxidant activity and inhibition of acetylcholinesterase as well as the absence of cytotoxicity against human cells were demonstrated and compared between samples.

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A New Sesquiterpenoid from the Fruiting Bodies of Amauroderma amoiensis

et al. 2023

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Phenolic Constituents with Inhibitory Activities on Acetylcholinesterase from the Rhizomes of Gastrodia elata

Cited by 6 publications

References 16 publications

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root

An Unsuccessful Attempt to Confirm the Occurrence of 4′-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root

Bioactivity Profiling and Quantification of Gastrodin in Gastrodia elata Cultivated in the Field versus Facility via Hyphenated High-Performance Thin-Layer Chromatography

A New Sesquiterpenoid from the Fruiting Bodies of Amauroderma amoiensis

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