Phenolic contents, antioxidant capacities and inhibitory activities against key metabolic syndrome relevant enzymes of herbal teas from Eastern Anatolia

Dalar, Abdullah; Konczak, Izabela

doi:10.1016/j.indcrop.2012.11.037

Cited by 106 publications

(81 citation statements)

References 28 publications

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“…Subsequently, the samples were ground and stored at 20 C until analyzed. The lyophilized extract was prepared as described previously 20 with some modifications.…”

Section: Plant Materials Extractmentioning

confidence: 99%

Histopathological and Immunohistochemical Study of Antidiabetic Effects of Heracleum persicum Extract İn Experimentally Diabetic Rats

Yaman¹,

Uyar²,

Çelik³

et al. 2017

IJPER

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Objective: This study aims to investigate the antioxidant properties and protective effects of Heracleum persicum (HP) extract in streptozotocin (STZ)-induced diabetic rats. Material and Methods: Forty-two Wistar albino male rats were divided into six groups including Control (C); Diabetes mellitus (DM); DM+Akarboz 20 mg/kg; DM+100 mg/kg HP extract (HP1); DM+200 mg/kg HP extract (HP2) and DM+400 mg/kg HP extract (HP3). Experimental diabetes was established by a single-dose [45 mg/kg, intra-peritoneal (i.p)] STZ injection. Essential dosages of HP extracts and Akarboz were applied with gastric gavage for 21 day. Results: In histopathological evaluation of the stained liver and kidney sections of diabetic rats showed degeneration and necrosis of hepatocytes, inflammatory cell infiltration and hydropic degeneration and necrosis in tubulus epithelial cells, disorder of glomerular structure and lymphocyte infiltration. These histopathological changes were ameliorated in the HP-treated rats depending on the dose level. Glutathione peroxidase 1 (GPx-1) immunoreactivity was detected in hepatocytes of liver and tubule epithelial cells of kidney. We have shown that treatment with extracts of HP modulates GPx-1 expression in HP-treated rats. STZ-induced degenerative changes in beta-cells caused decreases in the number of functioning beta-cells and insulin immunoreactivity in the pancreas of the diabetic rats. The pancreas of HP-treated rats were improved and the number of immunoreactive β cells were significantly increased. Conclusion: Our data suggests that the STZ-induced immunohistochemical and histopathological alterations could be prevented by HP extract probably due to possess the ability to regenerate β-cells.

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“…Subsequently, the samples were ground and stored at 20 C until analyzed. The lyophilized extract was prepared as described previously 20 with some modifications.…”

Section: Plant Materials Extractmentioning

confidence: 99%

Histopathological and Immunohistochemical Study of Antidiabetic Effects of Heracleum persicum Extract İn Experimentally Diabetic Rats

Yaman¹,

Uyar²,

Çelik³

et al. 2017

IJPER

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“…The lyophilized extract was prepared as described previously (Dalar & Konczak 2013) with some modifications. Briefly, the ground plant materials were mixed with a five-fold volume of purified water (g/ml), shaken for 2 h at room temperature (22 C) and centrifuged for 20 min with the supernatant collected.…”

Section: Plant Materials and Preparation Of Lyophilized Extractmentioning

confidence: 99%

Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats

Doğan

Çelik

2016

Pharmaceutical Biology

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Context Sumac [Rhus coriaria L. (RC) (Anacardiaceae)] is used as a folk medicine in the treatment of diabetes in Turkey. Objective This study investigates the in vivo healing and protective effects of lyophilized extract sumac against streptozotocin (STZ)-induced diabetic complications. Materials and methods Toxicity test was conducted in three different dosages (250, 500 and 1000 mg/kg of plant extracts, respectively). Six groups of seven rats each were used in experiments. Groups were designed as Normal control, Diabetic (DM), DM + AC-20 mg/kg, DM + Extract-100 mg/ kg, DM + Extract 250 mg/kg and DM + Extract 500 mg/kg group. Experimental diabetes [50 mg/kg, intraperitoneal (i.p.)] was induced by STZ. The effects of oral administration of the extract for 21 d on the level of serum glucose, insulin, C-peptide, lipid profile (LP), hepatic and renal damage biomarkers (HRDB), diabetic serum biomarkers (DSB), glycosylated haemoglobin (HbA1c), antioxidant defence system constituents (ADSCs), malondialdehyde (MDA) and a-glucosidase activity in small intestine tissue were evaluated. Results The extract decreased the levels of blood glucose in diabetic groups (an average of 31%). Triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were balanced by plant extract (500 mg/kg) supplementation in the diabetic group. Decreased levels of aspartate aminotransferase (89%), alanine aminotransferase (91%), lactate dehydrogenase (35%), alkaline phosphatase (47%), creatinine (25%) and urea (29%) were detected in plant extract (500 mg/kg) supplemented diabetic group. Additionally, a considerable increase in the HRDB, DSB, LP, MDA and fluctuated ADSC levels were restored in RC-extract supplemented groups. Conclusion RC lyophilized extract has a healing effect on diabetes and diabetes-related complications.ARTICLE HISTORY

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“…FRAP activities of all herbal teas brewed at different temperatures were found significantly different (p<0.05) from each other by Duncan's multiple range test. In a previous study; FRAP activity of ethanol-based lyophilized hydrophilic extracts prepared from herbal teas from Eastern Anatolia have been reported, ranging from 390.8 ± 13.5 to 1130.8 ± 48.2 μmol Fe 2+/ g dried weight [22]. …”

Section: Ferric Reducing Antioxidant (Frap) Activitymentioning

confidence: 95%

Antioxidant Properties of Some Herbal Teas (Green tea, Senna, Corn Silk, Rosemary) Brewed at Different Temperatures

Kiliç¹,

Can²,

Yılmaz³

et al. 2017

International Journal of Secondary Metabolite

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Some non-wood forest products are brewed and consumed as tea. Among the reasons for the consumption of herbal tea, digestive problems are located in the first row. Antioxidants help to human body for arranging digestive and immune system. Herbal tea is brewed in various ways such as boiling at different durations or waiting in hot water at different temperatures etc. Type of brewing can affect to bioactive properties of herbal tea. In this study, it was investigated the bioactive properties (total phenolic content, total flavonoid content, condensed tannin content and antioxidant properties) of some herbals brewed (Green tea / Camellia sinensis., senna / Cassia sp., corn silk / Zea mays, rosemary / Rosmarinus officinalis) at different temperature. These herbs were brewed for 10 minutes at 60 o C, 80 o C and 100 o C temperatures. After cooling, total phenolic, flavonoid content, total condensed tannin content and antioxidant properties of these herbs were determined. Consistently, the highest results were found in the tea brewed at 100 o C. The highest total flavonoid (0.305 ± 0.005 mg QE/g) and ferric reducing ability (670.150 ± 2.121 µmol FeSO47H2O/g) was in Rosmarinus officinalis. The highest condensed tannin (9.443 ± 0.524 mg CE/g) and the highest total phenolic content (4.872 ± 0.005 mg GAE/g) was in Camellia sinensis and Cassia sp., respectively.

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Phenolic contents, antioxidant capacities and inhibitory activities against key metabolic syndrome relevant enzymes of herbal teas from Eastern Anatolia

Cited by 106 publications

References 28 publications

Histopathological and Immunohistochemical Study of Antidiabetic Effects of Heracleum persicum Extract İn Experimentally Diabetic Rats

Histopathological and Immunohistochemical Study of Antidiabetic Effects of Heracleum persicum Extract İn Experimentally Diabetic Rats

Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats

Antioxidant Properties of Some Herbal Teas (Green tea, Senna, Corn Silk, Rosemary) Brewed at Different Temperatures

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