Phenolic, oxylipin and fatty acid profiles of the Chilean hazelnut (Gevuina avellana): Antioxidant activity and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes

Abstract

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Phytoprostanes and Phytofurans—Oxidative Stress and Bioactive Compounds—in Almonds are Affected by Deficit Irrigation in Almond Trees

“…In the present, only a few studies on PhytoPs in almonds, nuts, and olives have been reported ,,,, and scarce relationships have been established between agricultural practices like water management and these plant oxylipins. We hypothesize that water constrains/water stress leads to the synthesis of phytoprostanes and phytofurans on almonds and that such bioproducts may serve as indicators of water stress.…”

“…41 Besides being reliable biomarkers of OS, PhytoPs and PhytoFs are also lipid mediators. 39 PhytoPs have many health benefits such as (i) protecting cells against the damage produced under OS conditions, playing an important role in the immune and neuronal function regulation; (ii) interacting with gut microflora; and (iii) developing anti-inflammatory and apoptosis-inducing activities and (iv) as anti-oxidants 7,21,29,42−44 These actions have been recently associated with the structural similarities of PhytoPs and PhytoFs vs human oxylipins 44−46 In the present, only a few studies on PhytoPs in almonds, nuts, and olives have been reported 7,8,13,14,47 and scarce relationships have been established between agricultural practices like water management and these plant oxylipins. We hypothesize that water constrains/water stress leads to the synthesis of phytoprostanes and phytofurans on almonds and that such bioproducts may serve as indicators of water stress.…”

Phytoprostanes and phytofurans modulate COX-2-linked inflammation markers in LPS-stimulated THP-1 monocytes by lipidomics workflow

“…This experimental design allowed providing further insights into the specific inflammatory modulation of individual PhytoPs and PhytoFs by evaluating changes in the intracellular and extracellular concentration of the 7 PGs found in quantifiable amounts in THP-1 cells (15-keto-PGF 2α , PGF 2α , 11β-PGF 2α , PGE 2 , PGD 2 , PGDM, and PGF 1α ). Also, this work provides new complementary information with respect to previous descriptions of the biological functions of PhytoPs and PhytoFs, focused on the cytokines profile and/or the phenotype of immune-cells through earlier works which focused on a single plant oxylipin or complete plant extracts of PhytoPs and PhytoFs [30,34,[57][58][59][60][61]. In this regard, the use of whole extracts constitutes an approach that allows retrieving valuable results, but is limited in scope.…”

Berberis microphylla G. Forst (Calafate) Berry Extract Reduces Oxidative Stress and Lipid Peroxidation of Human LDL

“…Fatty acid methyl ester (FAME) derivatization was achieved using the AOAC 969.33 protocol for fatty acids [22] with Myristic-d-27 acid (75 mg/L) as the internal standard. The GC-MS analysis was performed using a 30 m × 0.25 mm × 0.2 µm ionic liquid SLB-IL-111 column from Supelco.…”