Phenolic profile, safety assessment, and anti-inflammatory activity of Salvia verbenaca L.

Righi, Nadjat; Boumerfeg, Sabah; Deghima, Amirouche; Fernandes, Pedro Alexandrino; Coelho, Elisabete; Baali, Faiza; Cardoso, Susana M.; Coimbra, Manuel A.; Baghiani, Abderrahmane

doi:10.1016/j.jep.2021.113940

Cited by 29 publications

(10 citation statements)

References 59 publications

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“…In another interesting study, Righi et al [ 29 ] evaluated the in vivo antiphlogistic potential of an hydromethanolic extract obtained from the aerial parts of this same Salvia species using a xylene-induced edema model. Mice treated with S. verbenaca extract reduced the weight increase caused by xylene, especially at 600 mg/kg of body weight that afforded 50% of edema inhibition.…”

Section: Pharmacological Wound Healing Evidence Of Iberian Lamiaceaementioning

confidence: 99%

“…Usually, Lamiaceae species are rich essential oil-bearing plants with a great diversity of phenolic compounds, polyphenols, iridoids, diterpenoids, triterpenoids, saponins and, in some restricted cases, pyridine and pyrrolidine alkaloids [ 21 ]. The presence of such compounds has been linked to a wide range of well-documented bioactivities, namely the antioxidant [ 7 , 22 , 23 , 24 , 25 ], anti-inflammatory [ 4 , 26 , 27 , 28 , 29 ] and especially antibacterial activity [ 22 , 23 , 25 , 30 , 31 , 32 , 33 ]. Altogether, this positively influences the wound healing potential of the Lamiaceae species.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

et al. 2023

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Skin tissue has a crucial role in protecting the human body from external harmful agents, preventing wounds that frequently demand proper healing approaches. The ethnobotanical knowledge of specific regions with further investigation on their medicinal plants has been paramount to create new and effective therapeutical agents, including for dermatological purposes. This review attempts, for the first time, to investigate the traditional applications of Lamiaceae medicinal plants that are already used by local communities in the Iberian Peninsula in wound healing. Henceforward, Iberian ethnobotanical surveys were reviewed, and the information about the traditional wound healing practices of Lamiaceae was comprehensively summarized. Afterwards, the scientific validation of each Lamiaceae species was exhaustively checked. From this, eight out of twenty-nine Lamiaceae medicinal plants were highlighted by their wound-related pharmacological evidence and are in-depth presented in this review. We suggest that future studies should focus on the isolation and identification of the active molecules of these Lamiaceae, followed by robust clinical trials that may confirm the security and effectiveness of such natural-based approaches. This will in turn pave the way for more reliable wound healing treatments.

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Section: Pharmacological Wound Healing Evidence Of Iberian Lamiaceaementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

et al. 2023

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“…On the other side, Salvia genus plants were used for food purposes and in popular medicine. While screening Salvia aegyptiaca and SV, previous studies showed their powerful antioxidant, antimicrobial (Belkhiri et al, 2017), anticancer (Jambor et al, 2020), immunomodulatory (Nassar et al, 2015), anti‐diabetic (Mamache et al, 2020) and anti‐inflammatory (Righi et al, 2021) activities. To the best of our knowledge, no previous studies have been conducted to assess the quality and fertility of cooled ram semen, diluted with the extender including different concentrations of SP or SV extracts.…”

Section: Introductionmentioning

confidence: 99%

Inclusion of Spirulina platensis and Salvia verbenaca extracts to boost semen quality and fertilization ability in sheep

Moula

Rahim

Chentouf³

et al. 2023

Reprod Domestic Animals

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The aim of this study was to investigate the effect of Spirulina platensis (SP) and Salvia verbenaca (SV) extracts added to skimmed milk (SM) extender on ram sperm quality and fertility. Semen was collected using an artificial vagina, extended in SM to reach a final concentration of 0.8 × 109 spermatozoa/mL, stored at 4°C and evaluated at 0, 5 H and 24 H. The experiment has been performed in three steps. Firstly, from four extracts (methanol: MeOH, acetone: Ac, ethyl acetate: EtOAc and hexane: Hex) of SP and SV, only acetonic and hexanoic extracts of SP and acetonic and methanolic extracts of SV showed the highest in vitro antioxidant activities and were then selected for the following step. Thereafter, the effects of four concentrations (1.25, 3.75, 6.25, and 8.75 μg/mL) of each selected extract on stored sperm motility were evaluated. The output of this trial led to select the best concentrations having beneficial effects on sperm quality parameters (viability, abnormalities, membrane integrity, and lipid peroxidation) and fertility after insemination. The results showed that the same concentration (1.25 μg/mL) of both Ac‐SP and Hex‐SP, as well as 3.75 μg/mL of Ac‐SV and 6.25 μg/mL of MeOH‐SV, maintain all sperm quality parameters at 4°C during 24 H of storage. Besides, no difference was found in fertility between the selected extracts and the control. In conclusion, SP and SV extracts were shown to improve the quality of ram sperm and to maintain fertility rate after insemination as similar or competitive to many previous studies published in the field.

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“…[ 20 ], S. rosmarinus Spenn. [ 21 ], S. plebeian [ 22 ], and S. verbenaca L. [ 23 ]); antioxidant (S. dracocephaloides Boiss. [ 24 ], S. multicaulis [ 25 ], S. pilifera [ 26 ], S. elegans , S. gerggii , and S. officinalis [ 27 ]); cytotoxic/anti-proliferative ( S. fruticosa Mill [ 28 ], S. macrosiphon Boiss.…”

Section: Introductionmentioning

confidence: 99%

Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities

et al. 2022

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The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus Salvia L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus Salvia, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from Salvia species, viz. C23-terpenoids, sesterterpenoids (C25), dammarane triterpenoids (C30), and uncommon triterpenoids (C20+C10). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated.

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Phenolic profile, safety assessment, and anti-inflammatory activity of Salvia verbenaca L.

Cited by 29 publications

References 59 publications

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

Inclusion of Spirulina platensis and Salvia verbenaca extracts to boost semen quality and fertilization ability in sheep

Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities

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