Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluation

Zengin, Gökhan; Atasagun, Bayram; Aumeeruddy, Muhammad Zakariyyah; Saleem, Hammad; Mollica, Adriano; Bahadori, Mir Babak; Mahomoodally, Mohamad Fawzi

doi:10.1016/j.indcrop.2018.11.027

Cited by 36 publications

(22 citation statements)

References 36 publications

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“…Major medicinal plant extracts showed some level of inhibitory activity against the AChE. This could be attributed to the phytochemicals mostly phenolic compounds present in the extract and their possible synergistic interaction effect [59][60][61][62][63][64]. To the best of authors knowledge, this is the first report on in vitro inhibition of the AChE enzyme by Zls extracts under the effect of ultrasound extraction where the interest of its application against Alzheimer's disease.…”

Section: Ache Inhibition Of Zls Extractmentioning

confidence: 83%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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Jujube plant is a potential source of polyphenols with biological propreties. The purpose of this study was to investigate the application of ultrasound technique for extracting phenolic compounds (TPC) from seeds of Zizyphus lotus under optimization conditions based on response surface methodology. A maximum TPC, total flavonoids content (TFC), and total condensed tannins content (TTC) of 2383.10 ± 0.87 mg GAE/100g, 486.50 ± 0.38 mg QE/100g and 15,787.10 ± 0.10 mg CE/100g, respectively obtained under ethanol concentration 50.16%, sonication temperature 29.01 °C, sonication time 15.94 min and solvent-to-solid ratio 34.10:1 mL/g. The optimized extract was then evaluated for its antioxidant, antiacethylcholinesterase, antihypercholesterolemia, and antiproliferative activities. The results showed that ultrasound method is a green and safe method that can be used to effectively extract TPC from jujube seeds. The biological activity of Zizyphus extract exhibited a very good antioxidant against DPPH (EC50 = 0.39 µg/mL) and FRAP (1670.42 ± 6.5 mg/100 g). Additionally, it possesses acetylcholinesterase (AChE) inhibitory effect (IC50 = 0.93 ± 0.01 mg/mL) and HMGR inhibition (45.41%) using 100 µg/mL. The extract significantly inhibits cell proliferation on the MCF-7 and HepG2 tumor cell lines with an IC50 values of <0.05 and 3 ± 0.55 mg/mL, respectively. Therefore, the ultrasound method can be considered a method for obtaining a significant anticancer activity with respect to the lines and therefore makes it possible to recover a maximum of phenolic compounds in less time with an AChE and HMGR inhibitory activity. Thus, it can be suggested that Zls extract is a promising fruit for the development of supplementary dietary due to its potential behaviour as nutraceutical.

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Section: Ache Inhibition Of Zls Extractmentioning

confidence: 83%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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“…The methanol extract of this plant showed the highest cupric reducing capacity (504.84 mg TE g −1 sample). Meanwhile, the dichloromethane extract of T. argaeus showed the highest metal chelating effect (36.41 mg EDTAE g –1 ) . Thyme extract was demonstrated to inhibit the production of Maillard browning products and possessed high antioxidant capacity .…”

Section: Biological Activitiesmentioning

confidence: 97%

“…Meanwhile, the dichloromethane extract of T. argaeus showed the highest metal chelating effect (36.41 mg EDTAE g -1 ). [106] Thyme extract was demonstrated to inhibit the production of Maillard browning products and possessed high antioxidant capacity. [107] Hot water extract of T. vulgaris leaf showed dosedependent DPPH-scavenging capability and it was similar to standard antioxidants butylhydroxyanisol (BHA) and butylated hydroxytoluene (BHT) at a dosage of 1.5 mg mL À 1 .…”

Section: In Vitromentioning

confidence: 99%

“…Furthermore, it improved the values of adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) in the liver and glucagon‐like peptide 1 (GLP‐1) in the pancreas . Compared with the decoction and methanolic extracts, the dichloromethane extracts of T. argaeus were the most effective butyrylcholinesterase and α ‐glucosidase inhibitors and the main compound rosmarinic acid ( 71 ) showed the highest Pa value (0.798) for antidiabetic activity . MS‐10, a combined herbal extract of Cirsium japonicum and T. vulgaris , produced changes in genes associated with the expression of tumor suppressor and bone health.…”

Section: Biological Activitiesmentioning

confidence: 99%

“…[127] Compared with the decoction and methanolic extracts, the dichloromethane extracts of T. argaeus were the most effective butyrylcholinesterase and α-glucosidase inhibitors and the main compound rosmarinic acid (71) showed the highest Pa value (0.798) for antidiabetic activity. [106] MS-10, a combined herbal extract of Cirsium japonicum and T. vulgaris, produced changes in genes associated with the expression of tumor suppressor and bone health. And it had the potential for improving women's menopausal symptoms, particularly bone health, without side effects.…”

Section: Other Activitiesmentioning

confidence: 99%

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Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Wang

et al. 2019

Chemistry & Biodiversity

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The genus Thymus (Lamiaceae) comprises about 214 species throughout the world, mainly found in North Africa, Europe, and temperate Asia zone. They are traditionally used as food additives and folk medicines. This review comprehensively summarizes information about traditional uses, chemical constituents, and biological activities of this genus and provides recommendations for future investigations. All information was gathered from scientific databases including Google Scholar, Sci‐Finder, Web of Science, ScienceDirect, and CNKI. Volatile oils are the most concerned constituents of this genus. Flavonoids, phenylpropanoids, tannins, organic acids, terpenoids, and phytosterols were also summarized. This genus plants possessed a variety of activities including antimicrobial, antioxidant, anti‐inflammatory, cytotoxic, analgesic, and antidiabetic. In brief, this review will be helpful to provide valuable data for explorations and create more interests towards Thymus genus in the future.

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Influence of drought stress and foliar application of chitosan on nutrient accumulation and phenolic composition of Thymus daenensis Celak

et al. 2023

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Changes in climate have intensified the drought in semi-arid regions. A shift toward cultivation of low-input crops, including high-value medicinal and herbal plants seems a more sustainable alternative strategy. A 2-year field study was conducted to investigate the influence of drought stress and chitosan on nutrient density and phenolic compounds of thyme. Treatments consisted of a factorial combination of three irrigation and three chitosan rates. Irrigation treatments consisted of keeping experimental plots at field capacity (no stress), irrigation when plots reached 50% of field capacity (mild stress), and irrigation when plots reached 25% of field capacity (severe stress). Chitosan rates were 0, 200, and 400 μL L −1 , while K + , and to some degree Ca +2 , accumulation increased by drought, N, P, and all micronutrients (Mn 2+ , Zn 2+ , Cu 2+ , and Fe 2+ ) decreased steadily as drought stress intensified. Drought stress reduced N and P by 23%-19% and 35%-23%, respectively, over the 2 years. Application of chitosan enhanced the accumulation of macro and micronutrients. Drought stress resulted in alterations in phenolic composition. In mature plants, almost all phenolic compounds, except thymol, increased as drought stress intensified. Cinnamic acid and rosmarinic contents, as the two major identified compounds, increased by 31% and 45%, respectively, under severe drought. Similar to drought, chitosan elicitation was more effective in elevating phenolic compounds in mature plants. The response of thyme to chitosan was independent of soil moisture availability. The results indicated that application of 400 μL −1 chitosan improved nutrient density and dry matter while significantly saved irrigation water.

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Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluation

Cited by 36 publications

References 36 publications

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Influence of drought stress and foliar application of chitosan on nutrient accumulation and phenolic composition of Thymus daenensis Celak

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