Phenomenology of Atypical Anxiety Disorders in Parkinson's Disease: A Systematic Review

Dissanayaka, N.; Forbes, Elana J.; Perepezko, Kate; Leentjens, Albert F.G.; Dobkin, Roseanne D.; Dujardin, Kathy; Pontone, Gregory M.

doi:10.1016/j.jagp.2022.02.004

Cited by 10 publications

(4 citation statements)

References 112 publications

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“…Current studies (Reijnders, J.S., et al, 2008) have found that the incidence of depression in PD patients worldwide is about 35%, and even more than 90% in some studies. The overall reported prevalence of PD anxiety disorders is 31 percent clinically on average (Broen, M.P., et al, 2016), which can exceed 50 percent considering neglected atypical anxiety presentations (Dissanayaka, N.N., et al, 2022). Sleep disturbances affect 40 to 90 percent of patients with PD (Suzuki, K., et al, 2015).…”

Section: Depression and Anxiety Play An Important Role In Pd Non-moto...mentioning

confidence: 99%

A Brief Analysis on the Modulation Effect of Ba Duan Jin on Non-Motor Symptoms of Parkinson’s Disease

Li²

2023

CRMS

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Parkinson’s disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. The non-motor symptoms of PD, such as depression and anxiety, are often ignored in the face of typical motor symptoms such as tremor and bradykinesia. Non-motor symptoms in PD will not only increase the burden of patients, affect the quality of life, but also reduce the effect of PD drug treatment. A vicious circle is formed. At present, PD cannot be cured. Drugs are the first-line treatment, but long-term use in clinical practice will bring various side effects. Clinical studies have shown that Ba duan Jin as an adjuvant treatment can improve the non-motor symptoms of PD and delay the progression of PD. However, the regulatory mechanism of Ba duan jin on non-motor symptoms of PD is still unclear, which needs to be further elaborated in combination with the theory of traditional Chinese medicine.

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Section: Depression and Anxiety Play An Important Role In Pd Non-moto...mentioning

confidence: 99%

A Brief Analysis on the Modulation Effect of Ba Duan Jin on Non-Motor Symptoms of Parkinson’s Disease

Li²

2023

CRMS

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“…[57][58][59][60] Anxiety Up to 40% of PD patients experience anxiety symptoms, including generalized anxiety disorder, panic attacks, and social phobia. [61][62][63] Clinically, anxiety and depression are highly comorbid; most patients with an anxiety disorder diagnosis also meet criteria for a depressive disorder, and vice versa. 64 Increasing anxiety and anxiety attacks have been associated with non-motor fluctuations (NMFs), particularly with dopaminergic medication wearing off (ie, "off" periods).…”

Section: Epidemiology and Neurobiology Depressionmentioning

confidence: 99%

“…Up to 40% of PD patients experience anxiety symptoms, including generalized anxiety disorder, panic attacks, and social phobia 616263. Clinically, anxiety and depression are highly comorbid; most patients with an anxiety disorder diagnosis also meet criteria for a depressive disorder, and vice versa 64.…”

Section: Epidemiology and Neurobiologymentioning

confidence: 99%

Management of psychiatric and cognitive complications in Parkinson’s disease

Weintraub

Aarsland

Biundo

et al. 2022

BMJ

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Neuropsychiatric symptoms (NPSs) such as affective disorders, psychosis, behavioral changes, and cognitive impairment are common in Parkinson’s disease (PD). However, NPSs remain under-recognized and under-treated, often leading to adverse outcomes. Their epidemiology, presentation, risk factors, neural substrate, and management strategies are incompletely understood. While psychological and psychosocial factors may contribute, hallmark PD neuropathophysiological changes, plus the associations between exposure to dopaminergic medications and occurrence of some symptoms, suggest a neurobiological basis for many NPSs. A range of psychotropic medications, psychotherapeutic techniques, stimulation therapies, and other non-pharmacological treatments have been studied, are used clinically, and are beneficial for managing NPSs in PD. Appropriate management of NPSs is critical for comprehensive PD care, from recognizing their presentations and timing throughout the disease course, to the incorporation of different therapeutic strategies (ie, pharmacological and non-pharmacological) that utilize a multidisciplinary approach.

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“…1,5 Anxiety in PD can meet DSM-V criteria, but also includes PD-specific symptomatology such as anxiety or distress related to motor symptoms 6 or experiences of increased anxiety with wearing off of dopaminergic therapies ("off-state" anxiety). 7 Such PD-specific anxiety symptomatology may be the reason for an increase in the use of the "Anxiety Not Otherwise Specified" designation following PD diagnosis. 6 Indeed, there is evidence to suggest the neuropathology of PD alters the neural circuitry of fear, which may delineate anxiety in PD from anxiety in the general population.…”

Section: Introductionmentioning

confidence: 99%

Anxiety in Parkinson’s Patients: What’s Timing Got to Do with It?

DeMarco

Zhang

Robinson

et al. 2023

J Geriatr Psychiatry Neurol

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Background: Parkinson’s Disease (PD) affects over 10 million people worldwide. Many PD patients experience comorbid anxiety disorders, which have been correlated with reduced quality of life and can manifest at any time during the course of PD, including prior to motor symptom onset. Purpose: Prior work has demonstrated that patients diagnosed with depression following a PD diagnosis are less likely to receive depression treatment, but no such study has been conducted for anxiety. Research Design: A cross-sectional analysis of secondary electronhic health record data was conducted. Study Sample: Data was obtained through Optum® de-identified Electronic Health Record dataset, using ICD-9 and ICD-10 diagnosis codes to determine PD status and comparing index date of anxiety and PD diagnoses to classify patients by relative time of diagnosis. Data Analysis: Multivariate logistic regression was performed to assess factors associated with receipt of mental health treatment. Results: Of PD patients with anxiety, 52% documented a diagnosis of anxiety prior to PD. Overall, 69% documented some treatment, with 79% of those diagnosed with anxiety prior to PD receiving some treatment compared to 59% of those diagnosed with anxiety on or after PD ( P < 0.001). Conclusion: Patients with PD and subsequent anxiety diagnoses are less likely to receive treatment. Further study could explore reasons for variations in mental health care within the context of an existing PD diagnosis.

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Phenomenology of Atypical Anxiety Disorders in Parkinson's Disease: A Systematic Review

Cited by 10 publications

References 112 publications

A Brief Analysis on the Modulation Effect of Ba Duan Jin on Non-Motor Symptoms of Parkinson’s Disease

A Brief Analysis on the Modulation Effect of Ba Duan Jin on Non-Motor Symptoms of Parkinson’s Disease

Management of psychiatric and cognitive complications in Parkinson’s disease

Anxiety in Parkinson’s Patients: What’s Timing Got to Do with It?

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