Phenothiazines Exhibiting Lesser Extraparamidal Manifestations

Phenothiazines as Anticholinergics

“…Since chemically related quaternary salts such as banthine and probanthine are well-known anticholinergic drugs, the authors speculated that quaternary oximes of phenothiazines might also exhibit enhanced anticholinergic activity. The CNS effects of a few phenothiazine oximes were already reported (1,2). Some other quaternary oximes of various 10-N-substituted phenothiazines (I-IX) synthesized in the authors' laboratory recently were, however, found to be devoid of any significant CNS-depressant activity (3).…”