Phenotype of Atopic Dermatitis With Food Allergy Predicts Development of Childhood Asthma via Gut Wnt Signaling

Lee, So‐Yeon; Kim, Sangrok; Kang, Mi Jin; Song, Kun-Baek; Choi, Eom Ji; Jung, Sungsu; Yoon, Jisun; Suh, Dong In; Shin, Youn Ho; Kim, Kyung Won; Ahn, Kangmo; Hong, Soo‐Jong

doi:10.4168/aair.2022.14.6.674

Cited by 4 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of the Wnt/β-catenin inhibitor ICG-001 in an AD-like murine model generated by repeated topical application of the hapten oxazolone (Ox) were examined, and ICG-001 was found to attenuate epidermal permeability barrier function in Ox-AD mice [ 111 ]. A longitudinal birth cohort study that involved 1699 children in Korea found that children with the AD phenotype in early life were closely related to the development of asthma only in the cases of accompanying food allergy (FA) [ 112 ]. Ingenuity pathway analysis (IPA) of the colonocyte transcriptome revealed that the differentiation of FA with AD was best described by the genes in ‘Wnt/β-catenin Signaling’, specifically AXIN1, CCND1, FZD2, and WNT6, indicating that this mechanism might be regulated by Wnt signaling [ 112 ].…”

Section: Discussion and Limitationsmentioning

confidence: 99%

“…A longitudinal birth cohort study that involved 1699 children in Korea found that children with the AD phenotype in early life were closely related to the development of asthma only in the cases of accompanying food allergy (FA) [ 112 ]. Ingenuity pathway analysis (IPA) of the colonocyte transcriptome revealed that the differentiation of FA with AD was best described by the genes in ‘Wnt/β-catenin Signaling’, specifically AXIN1, CCND1, FZD2, and WNT6, indicating that this mechanism might be regulated by Wnt signaling [ 112 ]. This pathway also has a strong link with TA.…”

Section: Discussion and Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis

Ouyang¹,

Goh

et al. 2023

IJMS

View full text Add to dashboard Cite

Atopic dermatitis and abnormalities in tooth development (including hypomineralization, hypodontia and microdontia) have been observed to co-occur in some patients. A common pathogenesis pathway that involves genes and protein interactions has been hypothesized. This review aims to first provide a description of the key gene mutations and signaling pathways associated with atopic dermatitis and tooth agenesis (i.e., the absence of teeth due to developmental failure) and identify the possible association between the two diseases. Second, utilizing a list of genes most commonly associated with the two diseases, we conducted a protein–protein network interaction analysis using the STRING database and identified a novel association between the Wnt/β-catenin signaling pathway (major pathway responsible for TA) and desmosomal proteins (component of skin barrier that affect the pathogenesis of AD). Further investigation into the mechanisms that may drive their co-occurrence and underlie the development of the two diseases is warranted.

show abstract

Section: Discussion and Limitationsmentioning

confidence: 99%

Section: Discussion and Limitationsmentioning

confidence: 99%

Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis

Ouyang¹,

Goh

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…However, innate inflammation markers (interleukin (IL)-1α, IL-1β, IL-8, IL-18) along with TARC (thymus and activation-regulated chemokine) and CTACK (cutaneous T cellattracting chemokine) were the most frequent finding in tape strip samples in correlation with AD severity in both lesional and non-lesional skin, while no significant correlations were observed in skin biopsy data [44]. Recently, in AD phenotypes that exhibit FA at early ages and progress to asthma later, a regulation by Wnt (Wingless and Int-1) signaling has been suggested [46].…”

Section: Risk Factors For Onset and Severitymentioning

confidence: 99%

The Multiple Trajectories of the Allergic March

de las Vecillas,

Quirce

2024

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

The allergic march has long responded to a scenario of the sequential appearance of different allergic comorbidities. However, the variability in the appearance and progression of different allergic diseases draws a heterogeneous scenario that does not respond to a linear and unique trajectory. Although currently almost half of the child population presents at least one allergy symptom, only 4-6% present multimorbidity, with several allergic entities coexisting. It has recently been shown that although they share etiological mechanisms and risk factors, these allergic diseases arise independently. In most cases a consecutive progression is not observed, or at least not the same in all patients. Inflammation mediated by T helper 2 (Th2) cells, epithelial barrier dysfunction and genetic predisposition plays a fundamental role in the etiology of these diseases, on which the interaction with the exposome acts decisively. Therefore, the study of diseases from an omics point of view is essential to describe the different trajectories of allergic progression and propose effective interventions to avoid multimorbidity scenarios. In this narrative review, we provide an overview of the current perception of allergic march, including clinical observations, omics data, risk factors, and preventative measures proposed for modifying its course or even preventing its onset.

show abstract

Removal of acidic dyes; acid yellow 25 and acid red 4 from wastewater by degassed activated carbon

Gul,

Alam,

Ilyas

et al. 2024

Pure and Applied Chemistry

View full text Add to dashboard Cite

Activated carbon was prepared at 300 °C and 600 °C, characterized by SEM, EDX and XRD, and was then used as an adsorbent for the removal of acidic dyes; acid yellow 25 and acid red 4. The activated carbon prepared at high temperature (600 °C) due to its high carbon contents and surface area was subsequently used as adsorbent for the selected dyes adsorption using batch adsorption approaches to estimate different adsorption parameters. For the estimation of kinetics and equilibrium parameters a number of kinetics and isotherm models were employed. Dyes were adsorbed on activated carbon surface at a high rate for the first 15 min, after which it began to diffuse into the micro pores and thus the process became steady. The rate constant was estimated for first and second order kinetics models. The maximum adsorption capacities recorded were 526.32 mg g−1 for acid red 4 and 555.55 mg g−1 for acid yellow 25. The enthalpy change values recorded were; 19.44 kJ mol−1 for acid yellow 25 adsorption and 16 kJ mol−1 for acid red 4 adsorption, meant that the process is endothermic. The negative values of Gibbs free energy change (−393.28, −1,515.48, −2,634.68 J mol−1) of acid red 4 and acid yellow 25 (−251.72, −1,058.06, −2,367.84 J mol−1) at tested temperatures, confirmed the feasibility and spontaneity of the adsorption processes. The adsorption of dyes on the carbon surface was diffusion-controlled process, as demonstrated by the linear graph of intraparticle diffusion model.

show abstract

Phenotype of Atopic Dermatitis With Food Allergy Predicts Development of Childhood Asthma via Gut Wnt Signaling

Cited by 4 publications

References 32 publications

Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis

Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis

The Multiple Trajectories of the Allergic March

Removal of acidic dyes; acid yellow 25 and acid red 4 from wastewater by degassed activated carbon

Contact Info

Product

Resources

About