Phenotype of bronchial asthma with obesity

Минеев, В. Н.; Лалаева, Т. М.; Васильева, Т. С.; Trofimov, V. I.

doi:10.18093/0869-0189-2012-0-2-102-107

Cited by 9 publications

(8 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Параллельное увеличение распространенности БА и ожирения вызвало широкий интерес научно-исследовательских коллективов к изучению клинико-патогенетических особенностей сочетанного течения данных хронических заболеваний [8]. Установлены более высокие показатели распространенности БА среди лиц с ожирением (9%) в сравнении с больными, не имеющими избыточной массы тела (5%) [9].…”

Section: фенотип бронхиальной астмы сочетанной с ожирениемunclassified

“…В связи с определенными признаками заболевания, обусловленными влиянием факторов внешней среды на генотип человека, БА и ожирение рассматривают не только как коморбидную патологию, но и как самостоятельный фенотип БА, который чаще встречается у лиц женского пола, характеризуется поздним дебютом, развитием системного воспаления и снижением ответа на терапию [8].…”

Section: фенотип бронхиальной астмы сочетанной с ожирениемunclassified

“…Минеева и соавт. установлено изменение его уровня в плазме крови при обострении и ремиссии БА [8]. Так, при обострении заболевания уровень лептина в плазме крови повышается, при ремиссии -снижается.…”

Section: механизмы формирования фенотипа бронхиальной астмы сочетаннunclassified

See 2 more Smart Citations

Metabolic aspects of the relationship of asthma and obesity

Kytikovа

Юрьевна²,

Аntonyuk

et al. 2019

Obes. metabol.

View full text Add to dashboard Cite

Asthma and obesity are serious medical and social world problems, and their combined course is characterized by a decrease in the quality of life, an increase in the frequency and duration of hospitalization. The present review summarizes the current views on the mechanisms of formation of asthma phenotype combined with obesity, role of leptin and adiponectin imbalance in the development of systemic inflammation in obesity in the pathophysiology of asthma, its interrelations with metabolic syndrome. We present data that shows that syndrome is closely related not only to the debut of asthma, but also to a decrease in its control. Along with obesity, the role of other components of metabolic syndrome, in particular insulin resistance, as a predictor of asthma development is considered. Insulin resistance may be the most likely factor in the relationship between asthma and obesity, independent of other components of the metabolic syndrome. Insulin resistance associated with obesity can lead to disruption of nitric oxide synthesis. We reveal common mechanism of metabolic disorders of nitric oxide and arginine in metabolic syndrome and asthma and show that insulin resistance treatment can be therapeutically useful in patients with asthma in combination with obesity.

show abstract

Section: фенотип бронхиальной астмы сочетанной с ожирениемunclassified

Section: механизмы формирования фенотипа бронхиальной астмы сочетаннunclassified

See 1 more Smart Citation

Metabolic aspects of the relationship of asthma and obesity

Kytikovа

Юрьевна²,

Аntonyuk

et al. 2019

Obes. metabol.

View full text Add to dashboard Cite

show abstract

“…Its prevalence on the Russian Federation territory is in the range from 1 to 12% [1,2]. In the last years there appeared many works about Ba frequently running in combination with hypertension disease, ischemic heart disease, diabetes mellitus (DM), obesity, and metabolic syndrome [1][2][3][4][5][6][7][8][9][10][11][12][13]. Ba was established to develop more often in obese patients than in general population [1][2][3][4].…”

mentioning

confidence: 99%

“…Various studies confirm a dosedependent association between these pathologies [1]. In comorbidity of Ba with a metabolic syndrome, its clinical course is usually more severe, with frequent exacerbations and admissions, a significantly lower spirometric indices, and even failure to control the patient's state in hospital conditions [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

mentioning

confidence: 99%

The Role of Modern Methods of Examination in Assessing the Effect of Smoking on the Course of Bronchial Asthma and Development of Comorbid Metabolic Pathology

Вахламов¹

2017

Sovrem Tehnol Med

View full text Add to dashboard Cite

Nizhny Novgorod State Medical academy, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russian FederationThe aim of the investigation was to demonstrate the feasibilities of using up-to-date methods of examination for assessing the effect of smoking on the course of bronchial asthma (Ba) and development of comorbid metabolic pathology.Materials and Methods. 201 patients with noncontrolled Ba were investigated. Group 1 comprised 152 nonsmoking patients, group 2 included 18 smokers, group 3 consisted of 31 heavy smokers. along with the general clinical methods of examination, external respiration function with evaluation of forced life capacity, forced expiratory volume in 1 second, and Tiffeneau index were investigated. To diagnose obesity, a bioelectrical impedance analysis was used, body mass index was determined, and waist measurements were performed. To study the carbohydrate metabolism, the level of glycated hemoglobin (Hba1c), immunoreactive insulin, and C-peptide were estimated.Results. waist measurements, bioelectrical impedance analysis, determination Hba1c, immunoreactive insulin, and C-peptide levels are established to play a great role in the diagnosis of comorbid endocrine pathology in Ba. The severity of the disease in Ba patients is aggravated by visceral obesity and diabetes mellitus, and cigarette smoking is an essential risk factor of their development. Longterm heavy smokers with Ba are characterized by the addition of chronic obstructive pulmonary disease and the development of overlap syndrome with an extremely severe course.

show abstract

Pathogenetic Aspects of the Phenotype of Bronchial Asthma Associated With Obesity

Uksumenko¹,

Антонюк²,

Аntonyuk³

2019

Bulletin Physiology and Pathology of Respiration

View full text Add to dashboard Cite

Currently, in parallel with the increase in the prevalence of asthma, there is an increase in the number of obese patients. The results of numerous studies indicate that the asthma phenotype in combination with obesity has well-defined clinical features – a more severe course with frequent exacerbations and reduced control of the disease. The article considers the main pathogenetic mechanisms that determine the development of the asthma phenotype in combination with obesity. The influence of excess adipose tissue in the chest on respiratory mechanics, the correlation of gastroesophageal reflux disease and respiratory depression in sleep are described. It is shown that the phenotype of asthma with obesity is characterized by inflammation of adipose tissue, adipokine imbalance, insulin resistance, and disturbance of vitamin D metabolism. Gender peculiarities and genetic condition of asthma associated with obesity are considered. Understanding general mechanisms underlying the formation of asthma and obesity will undoubtedly contribute to the development of new therapeutic strategies.

show abstract

Phenotype of bronchial asthma with obesity

Abstract: Phenotype of bronchial asthma with obesity

Cited by 9 publications

References 48 publications

Metabolic aspects of the relationship of asthma and obesity

Metabolic aspects of the relationship of asthma and obesity

The Role of Modern Methods of Examination in Assessing the Effect of Smoking on the Course of Bronchial Asthma and Development of Comorbid Metabolic Pathology

Pathogenetic Aspects of the Phenotype of Bronchial Asthma Associated With Obesity

Contact Info

Product

Resources

About