Phenotypic and genotypic characteristics of non-invasive S. pneumoniae isolates recovered from PCV10-vaccinated children in Bulgaria

Alexandrova, Alexandra; Pencheva, Daniela; Mitov, Ivan; Setchanova, Lena

doi:10.1016/j.ijmmb.2021.10.004

Cited by 2 publications

(4 citation statements)

References 27 publications

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“…An analogous trend has been observed, for example, in Bulgaria. PCV10 was introduced to the vaccination calendar in that country in 2010, and the percentage of vaccinated children increased from 69% in 2010 to 94% in 2011 [8,15]. Acceptance of vaccinations is a complex phenomenon, and receiving any vaccination depends on many factors.…”

Section: Discussionmentioning

confidence: 99%

Vaccination against Streptococcus pneumoniae in Children Born between 2015 and 2018 in Poland—How Has the Introduction of Free Compulsory Pneumococcal Vaccination Affected Its Uptake?

Malchrzak,

Babicki,

Mastalerz-Migas

2023

Vaccines

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Starting from 2017, pneumococcal vaccination was added to the Polish vaccination calendar as mandatory for all children born after 2016. The 10-valent conjugate vaccine was selected as mandatory and therefore free of charge. This paper aims to examine the impact of introducing mandatory vaccination on vaccine uptake. For this purpose, an analysis was conducted for 1595 vaccination record sheets from outpatient clinics in Wrocław and surrounding villages for children born 2015–2018. After the introduction of compulsory vaccination, the percentage of children fully vaccinated against pneumococcus increased (60.4% vs. 84.8%, p < 0.001). A significant decrease in the number of children who did not receive any dose of the vaccine was observed (27.8% to 3.3%, p < 0.001). The introduction of compulsory vaccination did not affect the completion of the pneumococcal schedule (11.8% vs. 11.9%). Compulsory PCV10 vaccination resulted in the less frequent choice of the 13-valent vaccine (72.3% vs. 19.9%, p < 0.001). More children in rural outpatient clinics were vaccinated against pneumococcus compared to urban outpatient clinics (84.8% vs. 70.8%, p < 0.001). The introduction of free pneumococcal vaccination increased the proportion of children vaccinated, although it did not affect the rate of discontinuation of the initiated schedule. In Poland, the increased popularity of the 10-valent vaccine at the expense of the 13-valent one translated into a change in the proportion of pneumococcal serotypes causing invasive pneumococcal disease.

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Section: Discussionmentioning

confidence: 99%

Vaccination against Streptococcus pneumoniae in Children Born between 2015 and 2018 in Poland—How Has the Introduction of Free Compulsory Pneumococcal Vaccination Affected Its Uptake?

Malchrzak,

Babicki,

Mastalerz-Migas

2023

Vaccines

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“…The most prevalent serotypes in the last years in our geographic area are 19A (13.8%), 6C (11.7%), 3 (9.6%), 15A (8.3%), and 23A (5.5%), which are non-PCV10 serotypes. 12 …”

Section: Discussionmentioning

confidence: 99%

“…In the post-vaccine era, the non-PCV10 serotype 19A emerged and occupied a leading position in the serotype distribution among vaccinated children. 12 The serotype 19A has successfully spread in our geographic area and a large number of 19A isolates developed multidrug resistance. 12 Our study disclosed a dual macrolide resistance for the tested strain.…”

Section: Discussionmentioning

confidence: 99%

“… 12 The serotype 19A has successfully spread in our geographic area and a large number of 19A isolates developed multidrug resistance. 12 Our study disclosed a dual macrolide resistance for the tested strain. Factors, such as high antibiotic consumption, vaccine pressure by the usage of PCVs, clonal expansion of existing clones, and the emergence of new clones, have been implicated in the wide distribution of serotype 19A isolates.…”

Section: Discussionmentioning

confidence: 99%

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