Phenotypic determinants of uncontrolled asthma

Siroux, Valérie; Boudier, Anne; Bousquet, Jean; Bresson, Jean‐Louis; Cracowski, Jean‐Luc; Ferran, Joane; Gormand, F.; Just, Jocelyne; Moual, Nicole Le; Morange, Sophie; Nadif, Rachel; Oryszczyn, Marie-Pierre; Pison, Christophe; Scheinmann, P.; Varraso, Raphäelle; Vervloët, D.; Pin, Isabelle; Kauffmann, F.

doi:10.1016/j.jaci.2009.06.010

Cited by 86 publications

(101 citation statements)

References 37 publications

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“…Asthma control may be difficult to define in epidemiology, although the validity of such a control scale was supported by epidemiological results [7,10]. Although all associations between asthmagens (known risk factors for asthma) and uncontrolled asthma were studied according to a priori hypotheses [5,6,8,13], it may be argued that our results regarding specific asthmagens require cautious interpretation due to multiple testing [33].…”

Section: Figurementioning

confidence: 84%

“…Epidemiological results also support the validity of such a control scale [7]. Few epidemiological studies have evaluated the environmental risk factors of asthma control [6,8]. For example, domestic exposures to products in spray form and air pollution have been found to be associated with poorly controlled asthma [6,9].…”

Section: Introductionmentioning

confidence: 83%

“…2) These associations are expected for adult-onset asthma but are unexpected for childhood-onset asthma [5]. Additional analyses were performed to assess the association between occupational exposure and each of the four asthma control domains (lung function, symptoms, exacerbations and activity limitations) [6,8] without including the exacerbation domain in the asthma control definition. To check the consistency of our main reported results, analyses were stratified by BMI, smoking habits, sex and sensitisation to common allergens, as previously suggested [13,20].…”

Section: Strategy Of Analysismentioning

confidence: 99%

“…Multidimensional scales following Global Initiative for Asthma (GINA) guidelines have been applied to define asthma control in epidemiology in both the European Community Respiratory Health Survey (ECRHS) and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) [6][7][8][9][10]. This measure of asthma control on a categorical scale, combining diurnal and nocturnal respiratory symptoms, asthma attacks, activity limitations, lung function and exacerbations, has not been formally validated.…”

Section: Introductionmentioning

confidence: 99%

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Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Moual¹,

Carsin²,

Siroux³

et al. 2013

Eur Respir J

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Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS).Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect.Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma.These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma. @ERSpublications Occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma in ECRHS II

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Section: Figurementioning

confidence: 84%

Section: Introductionmentioning

confidence: 83%

Section: Strategy Of Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Moual¹,

Carsin²,

Siroux³

et al. 2013

Eur Respir J

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“…The survey has already led to more than a hundred papers on the phenotypic, environmental, biological and genetic aspects with almost one third in collaboration with French, European or International research teams [3][4][5][6][7][8][9][10]. The scientific projects of the study are organized around 6 working groups (genetics, biology, phenotypes, occupational exposures, air pollution and nutrition).…”

mentioning

confidence: 99%

EGEA Collection: A Biobank Devoted to Asthma and Asthma-related Phenotypes

Nadif

Moual

Siroux

2017

Open Journal of Bioresources

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The Epidemiological study on the Genetics and Environment of Asthma (EGEA) is a 20-year cohort including cases with asthma (n = 388), their first degree relatives (n = 1244) and population-based controls (n = 415) recruited in the early 90's from five French cities. Participants were extensively characterized regarding environment and respiratory health, and a specific effort was made to trace and bank biological samples (ISO 9001 certification since 2006). Access to data and samples is opened to researchers wishing to develop new scientific collaborative programs. The survey has already led to more than a hundred papers with almost one third in collaboration with national and international teams.

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