Phenylpropanoid Sucrose Esters: Plant-Derived Natural Products as Potential Leads for New Therapeutics

Abstract

Natural products are regarded as vital key source of lead compounds for drug discovery due to their structural diversity and broad array of biological activities. Phenylpropanoid sucrose esters are naturally occurring compounds isolated from various plants and are structurally characterized by a sucrose core connected to one or more Ph-CH=CH-CO- moieties through an ester linkage. These compounds were extensively used in folk medicine and are found to possess many biological activities such as antitumor, antibacterial, antioxidant, antiviral, anti-inflammatory, neuro-protective and glycosidase inhibitory activities. This extensive review, which is the first of its kind on phenylpropanoid sucrose esters, aims to provide an up-to-date account of naturally occurring known phenylpropanoid sucrose esters with special focus on their sources, structures, biological and pharmacological activities.

Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model

“…Among these compounds, regaloside A was reported to have free radical scavenging activities (Panda et al, 2011), but no biological studies were performed for other compounds. Since 4-acetyl regaloside D was shown to have cyclooxygenase 1 (COX-1) and COX-2 inhibitory activities (Francis et al, 2004) and COX-2 was regarded as one of the major mediators in inflammatory response, further biochemical studies toward fishing out an active principles of LL extract including whether regaloside D attenuates CSinduced inflammation in animal models need to be performed.…”

Evaluation of anticandidal and antioxidant activities of phenolic compounds from Pyrostegia venusta (Ker Gawl.) Miers

“…This phenylpropanoid glycoside has numerous therapeutic effects; its antioxidant [31,36,37], kinase C inhibitor [38], immunomodulatory [39,40], hepatoprotective [41], anti-inflammatory [42][43][44], analgesic [45], and anti-asthmatic [46] actions have already been validated. Verbascoside has also been indicated to treat patients with the Parkinson disease, an oxidative stress-induced neurodegenerative condition [47].…”

Effects of LED lights on Expression of Genes Involved in Phenylpropanoid Biosynthesis and Accumulation of Phenylpropanoids in Wheat Sprout

“…Phenylpropanoids are present in fruits, vegetables, medicinal herbs (seeds, root, and leaves), and nuts [16,17]. Phenylpropanoids possess anti-inflammatory, antiviral, anti-allergenic, antibacterial, and antioxidant properties, which are beneficial to human health [18][19][20]. Phenylpropanoid is also reported to inhibit carcinogenesis and reduce the risk of diabetes and heart disease [21,22].…”