Phenytoin and Chlorpromazine in the Treatment of Spasticity

Cohan, Stanley; Raines, Arthur; Panagakos, Jean; Armitage, P

doi:10.1001/archneur.1980.00500550062008

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Phenytoin (Diphenylhydantoin Dilantin ® Diphenylan ® DI1

Phenothiazines1

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1985

2017

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Cited by 21 publications

(2 citation statements)

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“…140a The antispastic efficacy of phenytoin was evaluated in a controlled trial in patients with a variety of diagnoses. 141 Six of 10 patients had tone reduction from phenytoin at serum levels greater than 7 µg/mL, but with no doseresponse relationship beyond this threshold.The bothersome side effects of this drug are well known and it is unclear whether there is a patient population (apart from those already treated by phenytoin for associated epilepsy) that may benefit more from phenytoin than from more modern antispastic agents with less serious side effects. 5…”

Section: Phenytoin (Diphenylhydantoin Dilantin ® Diphenylan ® DImentioning

confidence: 92%

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Traditional pharmacological treatments for spasticity part II: General and regional treatments

Graciès¹,

Nance²,

Elovic³

et al. 1997

Muscle Nerve

184

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Section: Phenytoin (Diphenylhydantoin Dilantin ® Diphenylan ® DImentioning

confidence: 92%

“…The antispastic effect of chlorpromazine and some of its derivates has been clearly established in controlled studies [141][142][143][144] and may be related to alpha-adrenergic blockade (see above). Sedation was consistently a significant problem.…”

Section: Phenothiazinesmentioning

confidence: 99%